{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:48:39Z","timestamp":1791298119978,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A method has been developed for the quantitation of the antiepileptic drug vigabatrin (VGB) in human plasma. It is based on CE with LIF detection. The effect of the pH of the buffer and of <jats:italic>N<\/jats:italic>\u2010methylglucamine (GLC) as BGE constituent was investigated. The final BGE consisted of 50\u2005mM borate buffer, pH\u20059.0, with 100\u2005mM GLC and enabled separation within 12\u2005min at 20\u2005kV voltage. An SPE procedure was used for the pretreatment of biological samples, based on mixed\u2010mode lipophilic\u2010cation exchange cartridges, followed by a derivatization step with 6\u2010carboxyfluorescein\u2010<jats:italic>N<\/jats:italic>\u2010succinimidyl ester (CFSE). Fluorescence was excited by an Ar\u2010ion laser (<jats:italic>\u03bb<\/jats:italic><jats:sub>exc<\/jats:sub>\u2005=\u2005488\u2005nm). Linearity was observed in the 10\u2013120\u2005\u03bcg\/mL plasma concentration range. Extraction yield was &gt;96%, precision (expressed as RSD) &lt;6.7% and accuracy (recovery) was between 97.0 and 101.6%. The method has been successfully applied to the analysis of VGB in plasma of epileptic patients undergoing therapy with the drug.<\/jats:p>","DOI":"10.1002\/elps.200700139","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T06:46:30Z","timestamp":1189406790000},"page":"3535-3541","source":"Crossref","is-referenced-by-count":17,"title":["Determination of vigabatrin in human plasma by means of CE with LIF detection"],"prefix":"10.1002","volume":"28","author":[{"given":"Alessandro","family":"Musenga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mandrioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Comin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Kenndler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Augusta","family":"Raggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022393604014"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18376"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1499-1654.2000.001597.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.6.716"},{"key":"e_1_2_1_6_2","first-page":"447","volume":"6","author":"Patsalos P. 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