{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:39:28Z","timestamp":1780551568013,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid CE coupled with potential gradient detection (PGD) for the separation and detection of four quinolones, namely, enoxacin, ofloxacin (OFL), fleroxacin, and pazufloxacin, was described. Separation was performed in a fused\u2010silica capillary (75\u2005\u03bcm\u00d78.5\u2005cm) using a buffer of 30\u2005mM Tris and 4\u2005mM phosphoric acid at pH\u20058.9. Under the separation voltage of 3\u2005kV, the quinolones were separated within 2.8\u2005min with good linearity (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2005\u2265\u20050.985). The method was successfully applied in determining OFL in a pharmaceutical formulation. Also, a liquid\u2013liquid extraction (LLE) method was developed and coupled to CE\u2010PGD in determining quinolones that spiked in milk samples. With dichloromethane and hexane for enrichment and purification, the LLE recoveries of the four quinolones were in the range of 77\u2013106%. The detection limits of the quinolones with LLE\u2010CE\u2010PGD were from 23 to 65\u2005ng\/mL. The proposed CE\u2010PGD method was validated with an HPLC method, and the results indicated consistency between the two methods.<\/jats:p>","DOI":"10.1002\/elps.200700182","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T06:16:27Z","timestamp":1192601787000},"page":"4101-4107","source":"Crossref","is-referenced-by-count":27,"title":["A rapid CE\u2010potential gradient detection method for determination of quinolones"],"prefix":"10.1002","volume":"28","author":[{"given":"Yongxia","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00165-5"},{"key":"e_1_2_1_3_2","volume-title":"Quinolone Antimicrobial Agents","author":"Hooper D. C.","year":"1993"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-003-1749-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(99)00026-3"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"Council Regulation (EEC) No 2377\/90 Of 26 June 1990 laying down A community procedure for the establishment of maximum residue limits of veterinary medical products in foodstuff of animal origen","volume":"224","year":"1990","journal-title":"Off. J. Eur. Commun."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.06.018"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01048-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.11.110"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200400018"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0015265"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00641-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.02.022"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.03.025"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.02.057"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.11.080"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.07.037"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2003.09.055"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(01)00587-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(02)01398-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac061006v"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(96)00992-2"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(00)00884-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535709"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00214-6"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305656"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00595-8"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200209)23:17<3078::AID-ELPS3078>3.0.CO;2-F"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500868"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01019-5"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00814-7"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00071-5"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500178"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200500495"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500149"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(20000401)21:7<1405::AID-ELPS1405>3.0.CO;2-O"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00061-8"},{"key":"e_1_2_1_38_2","unstructured":"Li S. F. Y. Wei H. P. Zhang G. X. Potential Gradient Detector for Electrophoresis WO2000075650."},{"key":"e_1_2_1_39_2","unstructured":"Chiba T. Murata A. Electric Potential Gradient Detection\u2010Type Capillary Electrophoresis Detector JP 11108890."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200410293"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305471"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200406121"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573412054022743"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.05.055"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/elan.200503237"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305446"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac034064e"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.200700182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.200700182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:04:44Z","timestamp":1760526284000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.200700182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":46,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/elps.200700182"],"URL":"https:\/\/doi.org\/10.1002\/elps.200700182","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}