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The CDs were selected due to their frequent use in preformulation and drug formulation as oral excipients for the solubilization of drug substances with low aqueous solubility. ACE was demonstrated to be a feasible and efficient technique for investigation of the interactions between BS and \u03b2\u2010CDs. All the investigated BS possessed affinity for the three CDs with stability constants ranging from 2\u00d710<jats:sup>3<\/jats:sup> to 4\u00d710<jats:sup>5<\/jats:sup>\u2005M<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>. The requirements and assumptions related to the use of ACE for estimating high affinity stability constants were discussed. The extent and pattern of hydroxylation significantly influenced the affinity of the glyco\u2010 and tauro\u2010conjugated BS toward the \u03b2\u2010CDs (chenodeoxycholates\u2005&gt;&gt;\u2005deoxycholates\u2005&gt;\u2005cholates) whereas the nature of the \u03b2\u2010CD derivatization and BS conjugation played a minor role only. The results indicate that displacement of drug substances from \u03b2\u2010CD inclusion complexes is likely to occur in the small intestine where BS are present potentially influencing drug bioavailability.<\/jats:p>","DOI":"10.1002\/elps.200700311","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T05:49:16Z","timestamp":1190699356000},"page":"3745-3752","source":"Crossref","is-referenced-by-count":29,"title":["Complexation of tauro\u2010 and glyco\u2010conjugated bile salts with three neutral \u03b2\u2010CDs studied by ACE"],"prefix":"10.1002","volume":"28","author":[{"given":"Ren\u00e9","family":"Holm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik V.","family":"Nicolajsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune A.","family":"Hartvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Westh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7797-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960371r"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970015o"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/03602548108066011"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.52.900"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970025p"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600840306"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012136608249"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00004-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023037016997"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10443"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20198"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/1061027031000073207"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/la9817359"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2990725"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(91)90229-H"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.1395"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/la960803t"},{"key":"e_1_2_1_20_2","first-page":"5488","volume":"15","author":"Tan Z. 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