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However, the pretreatment of complex samples, which is unavoidable prior to CE\u2010MS analysis, is usually complicated and time\u2010consuming. In this work, we used voltage\u2010assisted SPE for the first time as an alternative to conventional treatments for preconcentrating and purifying analytes. To this end, we used a simple flow system coupled on\u2010line to CE\u2010MS equipment. The system is quite robust and provides reproducible peak areas (the precision ranges from 2.5 to 3.8%). Also, it provides increased sensitivity affording the determination of trace amounts (nanogram <jats:italic>per<\/jats:italic> liter levels) of analytes in only a few milliliters of sample. The proposed system was applied to the determination of members of two compound families (<jats:italic>viz.<\/jats:italic> tetracyclines and amines).<\/jats:p>","DOI":"10.1002\/elps.200700565","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T10:17:10Z","timestamp":1207909030000},"page":"2033-2040","source":"Crossref","is-referenced-by-count":23,"title":["Electrical field\u2010assisted solid\u2010phase extraction coupled on\u2010line to capillary electrophoresis\u2010mass spectrometry"],"prefix":"10.1002","volume":"29","author":[{"given":"Gabriel","family":"Morales\u2010Cid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolom\u00e9 M.","family":"Simonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Valc\u00e1rcel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0693870"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(03)01014-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(03)00605-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500800"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305542"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(00)00554-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500700"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200410267"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600340"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2004.04.050"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000801)21:14<2768::AID-ELPS2768>3.0.CO;2-P"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.240"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-003-2326-y"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2006.07.008"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.01.025"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.04.039"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.05.053"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600463"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-004-0480-9"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.05.103"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.05.077"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600312"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600429"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbbm.2006.11.005"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac9901182"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.200700565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.200700565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:16:37Z","timestamp":1760526997000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.200700565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/elps.200700565"],"URL":"https:\/\/doi.org\/10.1002\/elps.200700565","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"type":"print","value":"0173-0835"},{"type":"electronic","value":"1522-2683"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}