{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:39:48Z","timestamp":1760575188771,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Charcot\u2010Marie\u2010Tooth (CMT) disease is the most common inherited disorder of the human peripheral nerve, with an estimated overall prevalence of 17\u201040\/10\u2009000 [1]. The typical phenotype presents peroneal muscular atrophy and <jats:italic>pes cavus<\/jats:italic> [2]. CMT is usually divided into two large types, about two\u2010thirds of the patients have CMT type 1 (CMT1), that affects the layer of myelin (demyelination). In type 2 (CMT2) the nerve fibers are affected (axonal). CMT diseases have autosomal dominant, autosomal recessive, and X\u2010linked inheritance [1]. The most frequent subtype is 1A (CMT1A) with autosomal dominant transmission, secondary in most cases to a tandem duplication of a 1.5\u2005Mb DNA fragment on chromosome 17p11.2\u2010p12 [4\u20137]. In this region, the codification of the peripheral myelin protein 22 (PMP22) takes place. The severity of the disease varies among patients, even within the same family, from almost no symptoms to severe foot\u2010drop and sensory loss. The PMP22 gene has four exons and is regulated by two promoters located toward the extreme 5\u2032. The origin of the duplication that causes the disease is an uneven exchange of the chromatids during the meiosis. This unequal recombination occurs between two regions that limit the PMP22 gene, described as REP places of 24\u2005kb, proximal and distal [3, 4].<\/jats:p>","DOI":"10.1002\/elps.200700614","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T09:46:26Z","timestamp":1204537586000},"page":"1582-1584","source":"Crossref","is-referenced-by-count":1,"title":["Capillary electrophoresis for the detection of PMP22 gene duplication: Study in Mexican patients"],"prefix":"10.1002","volume":"29","author":[{"given":"Edgar","family":"Hern\u00e1ndez\u2010Zamora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"de la Luz Arenas\u2010Sordo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Maldonado\u2010Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:8:1:43"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.33588\/rn.3503.2002152","volume":"35","author":"Palau F.","year":"2002","journal-title":"Rev. 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