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For this purpose a 20\u2009mM borate buffer (pH 9.5) containing 20\u2009mM SDS and 12%\u2009v:v 2\u2010propanol was used as the background electrolyte. The samples were hydrodinamically injected for 6\u2009s, separated in a fused\u2010silica capillary at 25\u2009kV and 50\u00b0C and detected at 230\u2009nm. Under these conditions, the migration times for all the studied compounds ranged from 3.0 up to 8.0\u2009min. Linearity ranges were determined as 125\u20131500\u2009ng\/mL, whereas detection limits were from 37 to 120\u2009ng\/mL in biological samples and a value of 6\u2009ng\/mL in water samples. According to the validation study, the developed method was proved to be accurate, precise, sensitive, specific, rugged and robust. This method was applied to the analysis of different biological fluids at clinical levels, including two urine samples from patients undergoing treatment with LE or fluoxetine, and also to environmental samples at potentially polluting level. Prior to the determination, the samples were purified and pre\u2010concentrated by means of an extraction\u2013preconcentration step with a C<jats:sub>18<\/jats:sub> cartridge and by eluting the compounds with methanol.<\/jats:p>","DOI":"10.1002\/elps.200800495","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T06:02:26Z","timestamp":1233208946000},"page":"624-632","source":"Crossref","is-referenced-by-count":14,"title":["Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC"],"prefix":"10.1002","volume":"30","author":[{"given":"Juana","family":"Rodr\u00edguez\u2010Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Contento","family":"Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Mu\u00f1oz","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(82)90002-5"},{"key":"e_1_2_6_3_2","first-page":"2900","volume":"45","author":"Van Landeghem A. 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