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Three plasma polymer surfaces, <jats:italic>i.e.<\/jats:italic> tetraglyme, acrylic acid and allylamine, are tested. Results indicate EOF suppression in all plasma\u2010coated channels compared with the uncoated glass microchannel surfaces. The EOF behaviors of the modified microchannels after exposure to protein solutions are also investigated and show that even low levels of protein adsorption can significantly influence EOF behavior, and in some cases, result in the reversal of flow. The results also highlight that EOF measurement can be used as a method for detecting the presence of proteins within microchannels at low surface coverage (&lt;1\u2009ng\/cm<jats:sup>2<\/jats:sup> on glass). Critically, the results illustrate that the non\u2010fouling tetraglyme plasma polymer is able to sustain EOF. Comparison of the plasma\u2010polymerized surfaces with conventionally grafted polyelectrolyte surfaces demonstrates the stabilities of the plasma polymer films, enabling multiple EOF runs over 3 days without deterioration in performance. The results of this study clearly demonstrate that plasma polymers enable the surface chemistry of microfluidic devices to be tailored for specific applications. Critically, the deposition of the non\u2010fouling tetraglyme coating enables stable EOF to be induced in the presence of protein.<\/jats:p>","DOI":"10.1002\/elps.200800619","type":"journal-article","created":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T06:43:51Z","timestamp":1244616231000},"page":"1877-1887","source":"Crossref","is-referenced-by-count":33,"title":["Studies of electroosmotic flow and the effects of protein adsorption in plasma\u2010polymerized microchannel surfaces"],"prefix":"10.1002","volume":"30","author":[{"given":"Malinda","family":"Salim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1385\/159259798X"},{"key":"e_1_2_6_3_2","first-page":"537","volume-title":"Capillary Electrophoresis: Theory and Practice","author":"Camilleri P.","year":"1998"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500382"},{"key":"e_1_2_6_5_2","first-page":"65","volume-title":"Chip Capillary Electrophoresis and Total Genetic Analysis Systems, in New High Throughput Technologies for DNA Sequencing and Genomics","author":"Cheng Q. 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