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CE separation conditions, sheath liquid composition and electrospray parameters have been carefully optimized to reach high sensitivity and precision. Separation was carried out in a 96\u2009cm total length fused\u2010silica capillary (50\u2009\u03bcm id, 360\u2009\u03bcm od) using 60\u2009mM ammonium acetate at pH 6.0 as running buffer. Lomefloxacin was used as internal standard. MS\/MS experiments were carried out using an IT as analyzer operating in multiple reaction monitoring mode to achieve the minimum number of identification points established by the 2002\/657\/EC European Decision. The use of an SPE procedure in two steps, combining Oasis hydrophilic\u2013liphophilic balance and Alumina N cartridges provide a satisfactory preconcentration and clean up treatment for meat samples after extraction of the compounds with ACN. Only Oasis hydrophilic\u2013liphophilic balance cartridges were necessary in water samples to obtain adequate recoveries. The method has been characterized for its use in meat and water samples, using matrix\u2010matched calibrations. For chicken muscle samples, LODs between 8 and 12\u2009\u03bcg\/kg have been obtained, in all cases lower than the maximum residue limits permitted. For water samples LODs from 0.18 to 0.26\u2009\u03bcg\/L could ensure its satisfactory application in aquatic samples.<\/jats:p>","DOI":"10.1002\/elps.200800732","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T13:46:42Z","timestamp":1240494402000},"page":"1708-1717","source":"Crossref","is-referenced-by-count":33,"title":["Multiresidue determination of penicillins in environmental waters and chicken muscle samples by means of capillary electrophoresis\u2010tandem mass spectrometry"],"prefix":"10.1002","volume":"30","author":[{"given":"M. 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