{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:57:13Z","timestamp":1761310633644,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:00:00Z","timestamp":1277251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urine fingerprints from <jats:italic>Schistosoma mansoni<\/jats:italic> infected and control animals were acquired with ultra performance liquid chromatography\u2010MS (UPLC\u2010MS) and compared with the urine fingerprints obtained by CE by applying the same set of multivariate analysis tools. Principal component analysis of the aligned data provided a time trajectory where the infection was observed after 30 days with UPLC\u2010MS and CE. Two main markers describing infected and control, respectively \u2013 phenyl acetyl glycine (PAG) and hippurate \u2013 were selected to illustrate the use of orthogonal partial least\u2010square discriminant analysis in determining the discriminatory confidence. PAG was found to be significantly related to the disease (high covariance and correlation), whereas hippurate was found to be nonsignificant as an indicator. Orthogonal partial least\u2010square discriminant analysis models were validated for sensitivity and specificity. Multivariate data analysis derived from two different detection systems showed that CE\u2010UV and UPLC\u2010MS found equivalent results. This work gives additional mechanistic insight into the progress of the <jats:italic>S. mansoni<\/jats:italic> infection; the biochemical role and specificity of PAG as a biomarker is yet to be determined.<\/jats:p>","DOI":"10.1002\/elps.200900492","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T07:40:44Z","timestamp":1277278844000},"page":"2349-2355","source":"Crossref","is-referenced-by-count":17,"title":["Chemometric analysis of urine fingerprints acquired by liquid chromatography\u2010mass spectrometry and capillary electrophoresis: Application to the schistosomiasis mouse model"],"prefix":"10.1002","volume":"31","author":[{"given":"Isabel","family":"Garcia\u2010Perez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc E.","family":"Earll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coral","family":"Barbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Legido\u2010Quigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/b501767j"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.10.066"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700851"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.025"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800031"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800194"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.02.024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2006.03.008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr060685n"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr800407j"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cem.1006"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.5858\/2003-127-1637-SOTC","volume":"127","author":"Adeniran A.","year":"2003","journal-title":"Arch. 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