{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:40:30Z","timestamp":1760888430795,"version":"build-2065373602"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T00:00:00Z","timestamp":1269993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A CE assay for the simultaneous determination of charged and uncharged potential impurities (1<jats:italic>S<\/jats:italic>,2<jats:italic>S<\/jats:italic>\u2010(+)\u2010norpseudoephedrine, 1<jats:italic>R<\/jats:italic>,2<jats:italic>S<\/jats:italic>\u2010(\u2212)\u2010norephedrine, phenylacetone and phenylacetone oxime) of dexamphetamine sulfate including the stereoisomer levoamphetamine was developed and validated. The optimized background electrolyte consisted of a 50\u2009mM sodium phosphate buffer, pH 3.0, containing 80\u2009mg\/mL sulfobutylether\u2010\u03b2\u2010CD and 25\u2009mg\/mL sulfated \u03b2\u2010CD. Separations were performed in 40.2\/35\u2009cm, 50 \u03bcm id fused\u2010silica capillaries at a temperature of 20\u00b0C and an applied voltage of \u201310\u2009kV. 1<jats:italic>R<\/jats:italic>,2<jats:italic>S<\/jats:italic>\u2010(\u2212)\u2010ephedrine was used as internal standard. The assay was validated in the range of 0.05\u20131.0% for the related substances and in the range of 0.05\u20135.0% for levoamphetamine. The LOD was 0.01\u20130.02% depending on the analyte. The assay also allowed the separation of the E,Z\u2010stereoisomers of phenylacetone oxime. The effect of the degree of substitution of sulfobutylether\u2010\u03b2\u2010CD was investigated. In commercial samples of dexamphetamine sulfate between 3.2 and 3.7% of levoamphetamine were found. Furthermore, phenylacetone and phenylacetone oxime could be observed at the LOD, indicating the synthetic origin of the investigated samples.<\/jats:p>","DOI":"10.1002\/elps.200900724","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T12:21:35Z","timestamp":1270038095000},"page":"1475-1481","source":"Crossref","is-referenced-by-count":14,"title":["CE assay for simultaneous determination of charged and neutral impurities in dexamphetamine sulfate using a dual CD system"],"prefix":"10.1002","volume":"31","author":[{"given":"Sudaporn","family":"Wongwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunleu","family":"Sungthong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard K. E.","family":"Scriba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/108705470000300403"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.09.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.36.6.1076"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00175-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600670838"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.04.005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13824J"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-7368(69)70493-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-7368(81)71390-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19320650432"},{"key":"e_1_2_6_12_2","unstructured":"United States Pharmacopeia 32 Dextroamphetamine Sulfate The United States Pharmacopeial Convention Rockville MD2009."},{"key":"e_1_2_6_13_2","unstructured":"British Pharmacopoeia 2009 Dexamfetamine Sulphate The British Pharmacopoeia Convention London United Kingdom2009."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600650123"},{"key":"e_1_2_6_15_2","first-page":"848","volume":"64","author":"Wainer I. W.","year":"1981","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-458X(199803)36:3<211::AID-OMR246>3.0.CO;2-Y"},{"key":"e_1_2_6_17_2","first-page":"746","volume":"54","author":"Thunhorst M.","year":"1999","journal-title":"Pharmazie"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-1425(02)00305-0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00237a008"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600730835"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/25.1.38"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000601)21:10<1940::AID-ELPS1940>3.0.CO;2-#"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20021101)25:15\/17<959::AID-JSSC959>3.0.CO;2-Q"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305491"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600030"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.08.008"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800054"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.071"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800095"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800607"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-6395(07)00012-8"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.05.029"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600257"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200205)23:9<1328::AID-ELPS1328>3.0.CO;2-Z"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00392-3"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150191620"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150190109"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00094a026"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150180613"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00497-1"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990901)20:13<2698::AID-ELPS2698>3.0.CO;2-N"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.06.018"},{"key":"e_1_2_6_43_2","unstructured":"Guideline Q2(R1) Validation of Analytical Procedures: Text and Methodology International Conference on Harmonization 2005."},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305431"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500177"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00094a025"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)92633-X"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990901)20:13<2638::AID-ELPS2638>3.0.CO;2-Z"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501501113"},{"key":"e_1_2_6_50_2","first-page":"235","volume":"2","author":"Chankvetadze B.","year":"1995","journal-title":"J. Cap. Elec."},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(96)00067-5"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(92)80088-5"},{"key":"e_1_2_6_53_2","unstructured":"European Pharmacopoeia 6th Edn. Council of Europe Strasbourg France 2007."}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.200900724","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.200900724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:34:24Z","timestamp":1760520864000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.200900724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,26]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/elps.200900724"],"URL":"https:\/\/doi.org\/10.1002\/elps.200900724","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"type":"print","value":"0173-0835"},{"type":"electronic","value":"1522-2683"}],"subject":[],"published":{"date-parts":[[2010,4,26]]}}}