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Before analysis, the plasma samples were pretreated by liquid\u2013liquid extraction with ethyl acetate, and derivatized with 6\u2010carboxyfluorescein <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide ester. The chemical derivatization is performed with 6\u2010carboxyfluorescein <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide ester in ACN \u2013 5\u2009mM pH 9.0 borate buffer (40:60, v\/v) at 35\u00b0C for 3\u2009h. After the derivatization reaction, hydrodynamic injection (0.5\u2009psi, 8\u2009s) was used to introduce the derivatized solution, and the separation was performed in borate buffer (30\u2009mM, pH 9.5) with the nonionic surfactant Brij\u201035<jats:sup>\u00ae<\/jats:sup> (0.07%, w\/v); the separation voltage was 6\u2009kV. The linear ranges of the method for the determination of memantine and amantadine in human plasma were over a range of 2.0\u201360.0\u2009ng\/mL. The detection limit was 0.5\u2009ng\/mL (<jats:italic>S<\/jats:italic>\/<jats:italic>N<\/jats:italic>=3). This method was applied successfully to monitor the concentration of memantine or amantadine in patients with Alzheimer's disease or Parkinson's disease.<\/jats:p>","DOI":"10.1002\/elps.201000001","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T15:18:19Z","timestamp":1273072699000},"page":"1903-1911","source":"Crossref","is-referenced-by-count":40,"title":["Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser\u2010induced fluorescence detection and its clinical application"],"prefix":"10.1002","volume":"31","author":[{"given":"Hsin\u2010Hua","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Han","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Hwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.938"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666110-00015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00019-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000223333.42368.f1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.17221\/7884-VETMED","volume":"46","author":"Stani\u010dov\u00e1 J.","year":"2001","journal-title":"Vet. 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