{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:31:33Z","timestamp":1764873093164,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T00:00:00Z","timestamp":1280966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A CD\u2010modified microemulsion electrokinetic chromatography method has been developed and validated for dexamphetamine sulfate which allows the simultaneous determination of charged and uncharged impurities of the drug including the levorotary (<jats:italic>R<\/jats:italic>)\u2010enantiomer. The optimized background electrolyte consisted of 1.5%\u2009w\/w SDS, 0.5%\u2009w\/w ethyl acetate, 3.5%\u2009w\/w 1\u2010butanol, 2.5%\u2009w\/w 2\u2010propanol and 92%\u2009w\/w 50\u2009mM sodium phosphate buffer, pH 3.0, containing 5.5%\u2009w\/w sulfated \u03b2\u2010CD. Separations were performed in a 50.2\/40\u2009cm, 50\u2009\u03bcm id fused silica capillary at a temperature of 20\u00b0C and an applied voltage of \u221214\u2009kV. Carbamazepine was used as internal standard. The assay was validated in the range of 0.1\u20131.0% for the related substances and 0.1\u20135.0% for levoamphetamine based on a concentration of 3\u2009mg\/mL of dexamphetamine sulfate. The LOD of all analytes ranged between 0.05 and 0.2%. In commercial samples of dexamphetamine sulfate, levoamphetamine was found at concentrations between 3.2 and 3.8%, whereas none of the other impurities could be detected.<\/jats:p>","DOI":"10.1002\/elps.201000277","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T12:26:24Z","timestamp":1281097584000},"page":"3006-3011","source":"Crossref","is-referenced-by-count":20,"title":["Impurity profiling of dexamphetamine sulfate by cyclodextrin\u2010modified microemulsion electrokinetic chromatography"],"prefix":"10.1002","volume":"31","author":[{"given":"Sudaporn","family":"Wongwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard K. 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