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In this review, the most important and recent of these latter methods are reviewed and their main advantages and disadvantages are discussed. Particular attention is paid to the suitability of each method for the application to the biological matrix of interest: while all methods have been successfully applied for one or more biological tissues, to reach this goal they must overcome the sensitivity problem that is common to almost all capillary electrophoretic techniques. Most methods use one or more cyclodextrin derivatives as the chiral selector, thus the separation mechanism is not particularly complicated or unusual.<\/jats:p>","DOI":"10.1002\/elps.201000687","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T02:07:48Z","timestamp":1314842868000},"page":"2629-2639","source":"Crossref","is-referenced-by-count":11,"title":["Chiral analysis of amphetamines, methadone and metabolites in biological samples by electrodriven methods"],"prefix":"10.1002","volume":"32","author":[{"given":"Roberto","family":"Mandrioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mercolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Raggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.08.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-4575(94)00069-X"},{"key":"e_1_2_6_4_2","unstructured":"Christophersen A. 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