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Method validation has revealed similar quantification limit of 0.1\u2009\u03bcM of analytes using either of the labels, although LOD values were different: 7.8\u20139.8\u2009nM for 4\u2010fluoro\u20107\u2010nitro\u20102,1,3\u2010benzoxadiazole, 3.5\u2009nM for fluorescein\u20105\u2010isothiocyanate and 1.3\u20131.5\u2009nM for carboxyfluorescein succinimidyl ester derivatives. The almost two orders of magnitude difference between LOD and LOQ values is likely due to the unreliable derivatization reaction at low sample concentration. Based on the superior stability, FITC derivatization was used for the analysis of biological samples. The applicability of the method has been demonstrated by analyzing basal and potassium evoked amino acid concentrations in individual brain microdialysate samples.<\/jats:p>","DOI":"10.1002\/elps.201100032","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T06:25:35Z","timestamp":1319005535000},"page":"2816-2822","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of quantitative performance of three fluorescence labels in CE\/LIF analysis of aspartate and glutamate in brain microdialysate"],"prefix":"10.1002","volume":"32","author":[{"given":"Zsolt","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"T\u00e1bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Zachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Csillag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Sz\u00f6k\u0151","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/NP.1998.53"},{"key":"e_1_2_6_3_2","volume-title":"Basic Neurochemistry, Molecular, Cellular and Medical Aspects","author":"Siegel G. 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