{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:03:05Z","timestamp":1773478985844,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>GENTRANS, a comprehensive one\u2010dimensional dynamic simulator for electrophoretic separations and transport, was extended for handling electrokinetic chiral separations with a neutral ligand. The code can be employed to study the 1:1 interaction of monovalent weak and strong acids and bases with a single monovalent weak or strong acid or base additive, including a neutral cyclodextrin, under real experimental conditions. It is a tool to investigate the dynamics of chiral separations and to provide insight into the buffer systems used in chiral capillary zone electrophoresis (CZE) and chiral isotachophoresis. Analyte stacking across conductivity and buffer additive gradients, changes of additive concentration, buffer component concentration, pH, and conductivity across migrating sample zones and peaks, and the formation and migration of system peaks can thereby be investigated in a hitherto inaccessible way. For model systems with charged weak bases and neutral modified \u03b2\u2010cyclodextrins at acidic pH, for which complexation constants, ionic mobilities, and mobilities of selector\u2010analyte complexes have been determined by CZE, simulated and experimentally determined electropherograms and isotachopherograms are shown to be in good agreement. Simulation data reveal that CZE separations of cationic enantiomers performed in phosphate buffers at low pH occur behind a fast cationic migrating system peak that has a small impact on the buffer composition under which enantiomeric separation takes place.<\/jats:p>","DOI":"10.1002\/elps.201100472","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T11:37:26Z","timestamp":1335267446000},"page":"958-969","source":"Crossref","is-referenced-by-count":34,"title":["Dynamic high\u2010resolution computer simulation of electrophoretic enantiomer separations with neutral cyclodextrins as chiral selectors"],"prefix":"10.1002","volume":"33","author":[{"given":"Michael C.","family":"Breadmore","sequence":"first","affiliation":[{"name":"Australian Centre for Research on Separation Science, School of Chemistry University of Tasmania  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiu Ying","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Visceral Research University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitka","family":"Caslavska","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Visceral Research University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Thormann","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Visceral Research University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)00812-N"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/3527609431"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80145-K"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)01327-X"},{"key":"e_1_2_8_6_1","volume-title":"Capillary Electrophoresis in Chiral Analysis","author":"Chankvetadze B.","year":"1997"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.071"},{"key":"e_1_2_8_8_1","volume-title":"Chiral separations by capillary electrophoresis","author":"Van Eeckhaut A.","year":"2010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01042-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.08.072"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)85366-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(93)80056-E"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(93)80664-T"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100011a065"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00644-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900076"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900742"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900058"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900613"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac970513x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500756"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.12.022"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000517"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80374-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200405972"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600681"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305701"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800671"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000547"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(96)00943-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150180614"},{"key":"e_1_2_8_32_1","first-page":"XX","volume":"33","author":"Hru\u0161ka V.","year":"2012","journal-title":"Electrophoresis"},{"key":"e_1_2_8_33_1","first-page":"XX","volume":"33","author":"Svobodov\u00e1 J.","year":"2012","journal-title":"Electrophoresis"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6828855"},{"key":"e_1_2_8_35_1","volume-title":"The Dynamics of Electrophoresis","author":"Mosher R. A.","year":"1992"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150171223"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990901)20:13<2726::AID-ELPS2726>3.0.CO;2-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305493"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150190706"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600780"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00275-R"},{"key":"e_1_2_8_42_1","first-page":"282","volume":"18","author":"Ga\u0161 B.","year":"2005","journal-title":"LC\u2010GC Eur."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)90476-5"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.201100472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.201100472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:03:06Z","timestamp":1760554986000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.201100472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/elps.201100472"],"URL":"https:\/\/doi.org\/10.1002\/elps.201100472","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}