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A variety of submicron nanoparticulate entities including cell free circulating (cfc) <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, mitochondria, and virus can be isolated into <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> high\u2010field areas on microelectrodes, while blood cells and other micron\u2010size entities become isolated into <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> low\u2010field areas between the microelectrodes. The nanoparticulate entities are held in the <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> high\u2010field areas while cells are washed away along with proteins and other small molecules that are not affected by the <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> electric fields. <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> carried out on 20 \u03bcL of whole blood obtained from chronic lymphocytic leukemia patients showed a considerable amount of <jats:styled-content style=\"fixed-case\">SYBR G<\/jats:styled-content>reen stained <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fluorescent material concentrated in the <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> high\u2010field regions. Whole blood obtained from healthy individuals showed little or no fluorescent <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> materials in the <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> high\u2010field regions. Fluorescent <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>7 bacteriophage virus could be isolated directly from blood samples, and fluorescently stained mitochondria could be isolated from biological buffer samples. Using newer <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> microarray devices, high\u2010molecular\u2010weight <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> could be isolated from serum and detected at levels as low as 8\u201316 ng\/mL.<\/jats:p>","DOI":"10.1002\/elps.201200444","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T04:11:35Z","timestamp":1361506295000},"page":"1076-1084","source":"Crossref","is-referenced-by-count":78,"title":["Dielectrophoretic isolation and detection of cfc\u2010<scp>DNA<\/scp> nanoparticulate biomarkers and virus from blood"],"prefix":"10.1002","volume":"34","author":[{"given":"Avery","family":"Sonnenberg","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Y.","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"McCanna","sequence":"additional","affiliation":[{"name":"Biological Dynamics San Diego  CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajaram","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Biological Dynamics San Diego  CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rassenti","sequence":"additional","affiliation":[{"name":"UCSD Moores Cancer Center University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Kipps","sequence":"additional","affiliation":[{"name":"UCSD Moores Cancer Center University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla CA USA"},{"name":"Department of Nanoengineering University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3066"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2006.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(02)00077-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/117727190700200003"},{"key":"e_1_2_7_7_1","first-page":"4675","volume":"61","author":"Sozzi G.","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.123"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00091-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2006.11.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06581.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(87)90266-5"},{"key":"e_1_2_7_13_1","first-page":"e3037","volume":"59","author":"Lasser C.","year":"2012","journal-title":"J. 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