{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T22:53:43Z","timestamp":1766012023065,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"20-21","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"The aim of this study is to investigate genetic linkage and recombination fractions of 26 X chromosomal (X<\/jats:styled-content>\u2010STR<\/jats:styled-content>) loci with two multiplex PCR<\/jats:styled-content> systems (MX<\/jats:styled-content>15\u2010STR<\/jats:styled-content> and MX<\/jats:styled-content>12\u2010STR<\/jats:styled-content>). MX<\/jats:styled-content>15\u2010STR<\/jats:styled-content> (including DXS<\/jats:styled-content>7133, DXS<\/jats:styled-content>6801, DXS<\/jats:styled-content>981, DXS<\/jats:styled-content>6809, DXS<\/jats:styled-content>7424, DXS<\/jats:styled-content>6789, DXS<\/jats:styled-content>9898, DXS<\/jats:styled-content>7132, GATA<\/jats:styled-content>165B12, DXS<\/jats:styled-content>101, DXS<\/jats:styled-content>10075, DXS<\/jats:styled-content>6800, GATA<\/jats:styled-content>31E<\/jats:styled-content>08, DXS<\/jats:styled-content>10074, and DXS<\/jats:styled-content>10079) and MX<\/jats:styled-content>12\u2010STR<\/jats:styled-content> (including DXS<\/jats:styled-content>6854, DXS<\/jats:styled-content>9902, DXS<\/jats:styled-content>6800, GATA<\/jats:styled-content>172D<\/jats:styled-content>05, DXS<\/jats:styled-content>7423, HPRTB<\/jats:styled-content>, DXS<\/jats:styled-content>6807, DXS<\/jats:styled-content>6803, DXS<\/jats:styled-content>6804, DXS<\/jats:styled-content>6799, DXS<\/jats:styled-content>8378, and DXS<\/jats:styled-content>8377) were successful analyzed on 206 two\u2010generation families with two or more children and 33 three\u2010generation families with 72 grandsons. Segregation analysis and calculation of recombination fractions between pairs of markers were performed. Linkage analysis of pairs of markers showed that there existed significant linkage (maximum LOD<\/jats:styled-content> scores >2.0) within the physical distance of 48.5 Mb. Recombination events could be observed within the clusters of closed linked makers spanning <1.0 Mb. These results indicate that close cluster X<\/jats:styled-content>\u2010STR<\/jats:styled-content>s used and recombination fractions of the selected loci will be very useful for biostatistical calculations in complex kinship analysis.<\/jats:p>","DOI":"10.1002\/elps.201300204","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T12:44:38Z","timestamp":1378212278000},"page":"3016-3022","source":"Crossref","is-referenced-by-count":15,"title":["X chromosomal recombination\u2014A family study analyzing 26 X<\/scp>\u2010STR L<\/scp>oci in C<\/scp>hinese H<\/scp>an three\u2010generation pedigrees"],"prefix":"10.1002","volume":"34","author":[{"given":"Qiu\u2010Ling","family":"Liu","sequence":"first","affiliation":[{"name":"Faculty of Forensic Medicine Zhongshan School of Medicine Sun Yat\u2010Sen University Guangzhou P. R. China"},{"name":"Shanghai Key Laboratory of Forensic Medicine Institute of Forensic Sciences Ministry of Justice Shanghai P. R. 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