{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:46:31Z","timestamp":1787726791676,"version":"build-2784847793"},"reference-count":71,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000183","name":"U.S.\/Army Research Office","doi-asserted-by":"crossref","award":["#W911NF-11-1-0304"],"award-info":[{"award-number":["#W911NF-11-1-0304"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) diagnosis is increasing, with 1\/88 children believed to be affected by the disorder, with a most recent survey suggesting numbers as high as 1\/50. Treatment and understanding of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> causes is a pressing health concern. <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> protein biomarkers may provide clues about <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> cause. Protein biomarkers for <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s could be used for <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> diagnosis, subtyping, treatment monitoring, and identifying therapeutic targets. Here, we analyzed the sera from seven children with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and seven matched controls using <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ricine gel electrophoresis (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ricine\u2010<jats:styled-content style=\"fixed-case\">PAGE<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Overall, we found increased levels of apolipoproteins <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>po<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>po<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>4, involved in cholesterol metabolism and of serum paraoxanase\/arylesterase 1, involved in preventing oxidative damage, in the sera of children with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>, compared with their matched controls. All three proteins are predicted to interact with each other and are parts of high\u2010density lipoproteins. Further studies are needed to validate these findings in larger subject numbers.<\/jats:p>","DOI":"10.1002\/elps.201300370","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T06:42:58Z","timestamp":1396075378000},"page":"2046-2054","source":"Crossref","is-referenced-by-count":34,"title":["A pilot proteomic study of protein markers in autism spectrum disorder"],"prefix":"10.1002","volume":"35","author":[{"given":"Armand G.","family":"Ngounou Wetie","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Biochemistry and Proteomics Group Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Wormwood","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Biochemistry and Proteomics Group Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Thome","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Rostock  Rostock Germany"},{"name":"College of Medicine Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Dudley","sequence":"additional","affiliation":[{"name":"College of Medicine Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Taurines","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa G.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Biochemistry and Proteomics Group Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costel C.","family":"Darie","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Biochemistry and Proteomics Group Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","volume":"61","author":"Autism I.","year":"2012","journal-title":"MMWR Surveill. 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