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It is known that CE\u2010MS is an increasingly used and sought after technique for analysis in different fields such as environmental science, food analysis, biotechnology, pharmaceutical analysis, biomedical science, forensic science, toxicology, and genetic analysis. CE\u2010MS is particularly used in bio\u2010omic applications (proteomic, metabolomic, and also genomic applications) for the determination of biomarkers, disease diagnosis, and therapeutic treatment monitoring. Biomarker qualification, clinical proteomics, and its implementation in routine clinical analysis have certain limitations associated with reproducibility and analytical robustness. However, CE\u2010MS has been successfully used in numerous clinical applications in recent years when compared with other platforms. The main advantage lies in the availability of large comparable datasets that were all obtained by using the same procedure for sample preparation, analysis, and subsequent data evaluation. The scope of this review is to discuss the performance of CE\u2010MS as a platform for bio\u2010omics analysis and target\u2010based applications focusing on quadrupole (Q), IT, and TOF analyzers, and the types of bioapplications that apply to the particular analyzers. Papers and reviews that were published in 2012 and 2013 with relevant CE\u2010MS applications are considered in this review.<\/jats:p>","DOI":"10.1002\/elps.201300561","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T20:15:05Z","timestamp":1391199305000},"page":"2292-2308","source":"Crossref","is-referenced-by-count":54,"title":["Review of the CE\u2010MS platform as a powerful alternative to conventional couplings in bio\u2010omics and target\u2010based applications"],"prefix":"10.1002","volume":"35","author":[{"given":"Virginia Rodr\u00edguez","family":"Robledo","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Analytical Chemistry and Food Technology University of Castilla\u2014La Mancha (UCLM)  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Franklin","family":"Smyth","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences University of Ulster  Coleraine Northern Ireland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(96)00066-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700835"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000050"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-007-1486-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21347"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900189"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac8013669"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-061008-124934"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2010.09.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.199703"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio736"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100431"},{"key":"e_1_2_6_14_1","author":"Su\u00e1rez E. 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