{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:07:37Z","timestamp":1791587257551,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["12-03-31255"],"award-info":[{"award-number":["12-03-31255"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["12-03-00405"],"award-info":[{"award-number":["12-03-00405"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The first use of macrolide antibiotic clarithromycin (CLM) in nonaqueous media for enantioseparation (partial or baseline) of the following compounds: alprenolol, atenolol, metoprolol, clenbuterol, methoxyphenamine, pindolol, propranolol, sotalol, synephrine, labetalol, and fenoterol is reported. Each analysis took less than 15 min. To find optimal separation conditions, some properties of CLM (adsorption, solubility), as well as the effect of experimental parameters on the enantioseparation of analytes (background electrolyte composition, chiral selector concentration, temperature, and applied voltage) were studied. The best chiral resolution was achieved in methanolic solution of 100 mM citric acid, 10\u00a0mM NaOH, 240\u2013300 mM H<jats:sub>3<\/jats:sub>BO<jats:sub>3<\/jats:sub>, and 60\u201375 mM CLM. Using the proposed procedure, adsorption of CLM on the capillary wall was negligible and the repeatability of the migration times (RSD) was as good as 1.6%. For the analysis of propranolol, the linearity was achieved in the concentration range 2.5 \u00d7 10<jats:sup>\u22122<\/jats:sup>\u2013 3.0 \u00d7 10<jats:sup>\u22121<\/jats:sup> mg\/mL with the LODs (3 \u00d7 S\/N) being equal 2.6 \u00d7 10<jats:sup>\u22123<\/jats:sup> mg\/mL and 2.8 \u00d7 10<jats:sup>\u22123<\/jats:sup> mg\/mL for the first and the second enantiomers, respectively. Linear range for metoprolol enantiomers was 1.0 \u00d7 10<jats:sup>\u22122<\/jats:sup> \u20131.6 \u00d7 10<jats:sup>\u22121<\/jats:sup> mg\/mL. The LODs (3 \u00d7 S\/N) were determined as 2.8 \u00d7 10<jats:sup>\u22123<\/jats:sup> and 3.0 \u00d7 10<jats:sup>\u22123<\/jats:sup> mg\/mL for the first and the second enantiomers, respectively.<\/jats:p>","DOI":"10.1002\/elps.201400135","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:09:52Z","timestamp":1407283792000},"page":"2759-2764","source":"Crossref","is-referenced-by-count":28,"title":["Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis"],"prefix":"10.1002","volume":"35","author":[{"given":"Margarita V.","family":"Lebedeva","sequence":"first","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra F.","family":"Prokhorova","sequence":"additional","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Shapovalova","sequence":"additional","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg A.","family":"Shpigun","sequence":"additional","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac800662y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300222"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2040(09)60078-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200012)21:18<4159::AID-ELPS4159>3.0.CO;2-G"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900738"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.08.063"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-263-6_19"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.02.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2950"},{"key":"e_1_2_8_11_1","first-page":"280","volume":"3","author":"Hou J. G.","year":"2002","journal-title":"Chin. Chem. Lett."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1081\/AL-120021098"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-010-1647-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.01.035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000630"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.12.106"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337-012-2347-9"},{"key":"e_1_2_8_18_1","first-page":"1806","volume":"1217","author":"Chen B.","year":"2010","journal-title":"Electrophoresis"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.02.073"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbbm.2007.10.004"},{"key":"e_1_2_8_21_1","volume":"25","author":"Servais A.\u2010C.","year":"2004","journal-title":"Electrophoresis"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.09.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2004.04.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac071009n"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.201400135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.201400135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:12:15Z","timestamp":1760519535000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.201400135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,19]]},"references-count":23,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/elps.201400135"],"URL":"https:\/\/doi.org\/10.1002\/elps.201400135","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,19]]}}}