{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:55:02Z","timestamp":1790060102001,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Inflammatory processes and other failures related to the immune system are common features associated with Alzheimer's disease (AD), in both brain and the peripheral system. Thus, the study of the main organs of the immune system may have a great potential for the elucidation of pathological mechanisms underlying these abnormalities. This is the first metabolomic investigation performed in spleen and thymus from transgenic mice of AD. Tissues were fingerprinted using a metabolomic platform comprising GC\u2010MS and ultra\u2010HPLC\u2010MS. Multivariate statistics demonstrated significant differences in numerous metabolites between the APP\/PS1 mice and wild\u2010type controls, and it was proven that multiple biochemical pathways are disturbed in these organs including abnormal metabolism of phospholipids, energy deficiencies, altered homeostasis of amino acids, oxidative stress, and others. Therefore, these findings highlight the importance of the proper metabolic functioning of peripheral immune system in the development of neurodegenerative disorders such as AD.<\/jats:p>","DOI":"10.1002\/elps.201400450","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T03:24:11Z","timestamp":1415849051000},"page":"577-587","source":"Crossref","is-referenced-by-count":30,"title":["Metabolomics reveals significant impairments in the immune system of the APP\/PS1 transgenic mice of Alzheimer's disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Ra\u00fal","family":"Gonz\u00e1lez\u2010Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Department of Chemistry and CCMM Faculty of Experimental Sciences University of Huelva  Campus de El Carmen Huelva Spain"},{"name":"Campus of Excellence International ceiA3 University of Huelva  Huelva Spain"},{"name":"Research Center of Health and Environment (CYSMA) University of Huelva  Campus de El Carmen Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Garc\u00eda\u2010Barrera","sequence":"additional","affiliation":[{"name":"Department of Chemistry and CCMM Faculty of Experimental Sciences University of Huelva  Campus de El Carmen Huelva Spain"},{"name":"Campus of Excellence International ceiA3 University of Huelva  Huelva Spain"},{"name":"Research Center of Health and Environment (CYSMA) University of Huelva  Campus de El Carmen Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Vitorica","sequence":"additional","affiliation":[{"name":"Department Bioqu\u00edmica, Bromatologia, Toxicolog\u00eda y Medicina Legal Faculty of Pharmacy, University of Seville  Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Seville Spain"},{"name":"Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Roc\u00edo\/CSIC\/University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"G\u00f3mez\u2010Ariza","sequence":"additional","affiliation":[{"name":"Department of Chemistry and CCMM Faculty of Experimental Sciences University of Huelva  Campus de El Carmen Huelva Spain"},{"name":"Campus of Excellence International ceiA3 University of Huelva  Huelva Spain"},{"name":"Research Center of Health and Environment (CYSMA) University of Huelva  Campus de El Carmen Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02264"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00040-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.080895"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.07.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.09.018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/756357"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.07.023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2011.06.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245156"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:7:3:255"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079197"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.10.071"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0610-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac303163f"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11696-012-0184-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.07.075"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.01.014"},{"key":"e_1_2_8_20_1","author":"Gonz\u00e1lez\u2010Dom\u00ednguez R.","year":"2014","journal-title":"Electrophoresis"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac301243k"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.06.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.11.017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.04.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0516-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300582p"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh019"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9011599"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/b604498k"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.04.021"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051437y"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac201065j"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-142"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800095-JLR200"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.10061"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.12.057"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01838-1"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq418"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9291-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-6871-3"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024777"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00035-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(98)00105-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.07.032"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31826be03c"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.274142"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9673-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2007.06.001"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20474"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000022031"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01705539"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.06.002"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04911.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-012-8173-2"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.06.001"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.18"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.09.019"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100630"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.05.023"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1668"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310040003"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1002"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.11.047"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.489"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513488925"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711450769936X"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.201400450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.201400450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:48:22Z","timestamp":1760532502000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.201400450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/elps.201400450"],"URL":"https:\/\/doi.org\/10.1002\/elps.201400450","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]}}}