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This present study showed that small amount of NaCl (\u22640.005 mg\/mL) in the sample had no impact on the separation but enhanced the sensitivity. However, when concentration of NaCl increased above 0.005 mg\/mL, it alleviated the separation efficiency, sensitivity, and migration time. Besides, increasing NaCl concentration resulted in increasing turning point. The study of relationship of current and NaCl concentration indicated that when the TP of a sample is higher than 62.36 \u03bcA, desalination is necessary. Since the reported desalination methods are either expensive or complicated, we developed a simple and economic method by simply adding 12 times (volume) of chloroform\/methanol (2:1, v\/v) into the sample. When applied this method to turtle jelly, the number of theoretical plate (<jats:italic>N<\/jats:italic>) of 20 amino acids got up to threefold enhancement.<\/jats:p>","DOI":"10.1002\/elps.201400533","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T07:22:47Z","timestamp":1426576967000},"page":"1186-1195","source":"Crossref","is-referenced-by-count":3,"title":["Improvement of reproducibility and sensitivity by reducing matrix effect in micellar electrokinetic chromatography for determination of amino acids in turtle jelly"],"prefix":"10.1002","volume":"36","author":[{"given":"Lin\u2010Qiu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR P. R. 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