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For this purpose, plasma samples from wild\u2010type (wt) and HD (R6\/1) mice of different ages (8, 12, and 30 weeks), were analyzed by C<jats:sub>18<\/jats:sub>\u2010SPE\u2010CE\u2010MS in order to obtain the characteristic electrophoretic profiles of low molecular mass compounds. Then, multivariate curve resolution alternating least squares (MCR\u2010ALS) was applied to the multiple full scan MS datasets. This strategy permitted the resolution of a large number of metabolites being characterized by their electrophoretic peaks and their corresponding mass spectra. A total number of 29 compounds were relevant to discriminate between wt and HD plasma samples, as well as to follow\u2010up the HD progression. The intracellular signaling was found to be the most affected metabolic pathway in HD mice after 12 weeks of birth, when mice already showed motor coordination deficiencies and cognitive decline. This fact agreed with the atrophy and dysfunction of specific neurons, loss of several types of receptors, and changed expression of neurotransmitters.<\/jats:p>","DOI":"10.1002\/elps.201500378","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T12:50:50Z","timestamp":1450443050000},"page":"795-808","source":"Crossref","is-referenced-by-count":32,"title":["Metabolic profiling for the identification of Huntington biomarkers by on\u2010line solid\u2010phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools"],"prefix":"10.1002","volume":"37","author":[{"given":"Laura","family":"Pont","sequence":"first","affiliation":[{"name":"Departament de Qu\u00edmica Anal\u00edtica, Facultat de Qu\u00edmica Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Benavente","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica Anal\u00edtica, Facultat de Qu\u00edmica Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Jaumot","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry IDAEA\u2010CSIC  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e0","family":"Tauler","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry IDAEA\u2010CSIC  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Alberch","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cel\u00b7lular, Immunologia i Neuroci\u00e8ncies, Facultat de Medicina Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d\u2032Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Gin\u00e9s","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cel\u00b7lular, Immunologia i Neuroci\u00e8ncies, Facultat de Medicina Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d\u2032Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica Anal\u00edtica, Facultat de Qu\u00edmica Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Sanz\u2010Nebot","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica Anal\u00edtica, Facultat de Qu\u00edmica Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.281"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.12.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JHD-140117","volume":"3","author":"den Bogaard S. 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