{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:16:30Z","timestamp":1777634190501,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Leading Research Laboratory Program","award":["NRF-"],"award-info":[{"award-number":["NRF-"]}]},{"name":"National Leading Research Laboratory Program","award":["2013R1A2A1A05006378"],"award-info":[{"award-number":["2013R1A2A1A05006378"]}]},{"name":"Bio & Medical Technology Development Program","award":["NRF-2015M3A9B3028685"],"award-info":[{"award-number":["NRF-2015M3A9B3028685"]}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cooperative Research Program for Agricultural Science and Technology Development","award":["PJ009842"],"award-info":[{"award-number":["PJ009842"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Monodispersed lipid vesicles have been used as a drug delivery vehicle and a biochemical reactor. To generate monodispersed lipid vesicles in the nano\u2010 to micrometer size range, an extrusion step should be included in conventional hand\u2010shaking method of lipid vesicle synthesis. In addition, lipid vesicles as a drug carrier still need to be improved to effectively encapsulate concentrated biomolecules such as cells, proteins, and target drugs. To overcome these limitations, this paper reports a new microfluidic platform for continuous synthesis of small\u2010sized (\u223c10 \u03bcm) giant unilamellar vesicles (GUVs) containing quantum dots (QDs) as a nanosized model drug. To generate GUVs, we introduced an additional cross\u2010flow to break vesicles into small size. 1,2 \u2010 dimyristoyl\u2010sn\u2010glycero \u2010 3 \u2010 phosphocholine (DMPC) in an octanol\u2013chloroform mixture was used in the construction of self\u2010assembled membrane. Consequently, we have successfully demonstrated the fabrication of monodispersed GUVs with 7\u221212 \u03bcm diameter containing QDs. The proposed synthesis method of cell\u2010sized GUVs would be highly desirable for applications such as multipurpose drug encapsulation and delivery.<\/jats:p>","DOI":"10.1002\/elps.201600035","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T09:48:24Z","timestamp":1456566504000},"page":"1353-1358","source":"Crossref","is-referenced-by-count":5,"title":["On\u2010chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots"],"prefix":"10.1002","volume":"37","author":[{"given":"Youn\u2010Hee","family":"Park","sequence":"first","affiliation":[{"name":"Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do\u2010Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eujin","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je\u2010Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.anchem.1.031207.112747"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi2010017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/la100879p"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc03142a"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar8002442"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0613479"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/22\/45\/454105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900382"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/b923299k"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/am101191d"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja109137s"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902182"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC00520E"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja802157y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000798"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-0233\/17\/12\/S01"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/la070051a"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2005.06.008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn901433u"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-013-7303-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC01277A"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/la060094b"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.201600035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.201600035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.201600035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:58:15Z","timestamp":1760540295000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.201600035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1002\/elps.201600035"],"URL":"https:\/\/doi.org\/10.1002\/elps.201600035","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}