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An MSS (micelle to solvent stacking) approach was evaluated to enhance method sensitivity. This method considers composition of the micellar sample solution matrix and the injection time. Several analytical conditions influencing the resolution of the drugs mixture as pH and buffer concentration, organic solvent content, were also investigated. The base\u2010line separation of all studied analytes in the same run was achieved within 18 min in an uncoated fused silica capillary (50 \u03bcm id \u00d7 60 cm) using a background solution containing 50 mM phosphate buffer pH 2.5 and 30% ACN v\/v. Other experimental parameters such as applied voltage and capillary temperature were set up at 20 kV and 20\u00b0C, respectively. LOD values ranging between 15 and 75 ng\/mL for all studied compounds were obtained. From a comparison with conventional CZE, the proposed method provides an increase of sensitivity (39\u2010 to 55\u2010fold enhancement factor). Under optimal MSS\u2010CZE conditions, good linearity was achieved (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> \u2264 0.9998). The method was finally applied to the analysis of urine samples spiked with a standard mixture after a sample pretreatment, reaching satisfactory recovery values.<\/jats:p>","DOI":"10.1002\/elps.201600312","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T14:57:39Z","timestamp":1473433059000},"page":"2875-2881","source":"Crossref","is-referenced-by-count":14,"title":["Online sample concentration and analysis of drugs of abuse in human urine by micelle to solvent stacking in capillary zone electrophoresis"],"prefix":"10.1002","volume":"37","author":[{"given":"Zeineb","family":"Aturki","sequence":"first","affiliation":[{"name":"Istituto di Metodologie Chimiche Consiglio Nazionale delle Ricerche  Monterotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Fanali","sequence":"additional","affiliation":[{"name":"Istituto di Metodologie Chimiche Consiglio Nazionale delle Ricerche  Monterotondo 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