{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:55:53Z","timestamp":1760889353249,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>The enantiomers of praziquantel, the drug of choice in schistosomiasis, were separated by electrokinetic chromatography with cyclodextrins. Nine anionic cyclodextrins were screened for their ability to discriminate between the uncharged enantiomers. Seven investigated selectors presented chiral interactions with the enantiomers, these cases being interpreted in terms of stability constants and complex mobilities. The best results were delivered by sulfated\u2010\u03b2\u2010cyclodextrin, where quasi\u2010equal stability constants were accompanied by extreme selectivity values and was explained on the basis of highly different mobilities of the transient diastereomeric complexes. Since the enantiomer migration order was unfavorable, a simple polarity switch was employed (detection end at anode), which apart from migration order reversal, also resulted in extreme resolution values (<jats:italic>R<jats:sub>s<\/jats:sub><\/jats:italic> &gt; 35) and increased migration times. After optimization (50 mM phosphate buffer pH 2.0, supplied with 15 mM sulfated\u2010\u03b2\u2010cyclodextrin, 15 kV, capillary temperature 25\u00b0C, short\u2010end injection with 50 mbar \u00d7 2\u00a0s), analysis time under 10\u00a0min were obtained, while still maintaining high resolution (<jats:italic>R<jats:sub>s<\/jats:sub><\/jats:italic> &gt; 10). The method was validated according to the ICH guidelines and application of the method was tested on in\u2010house synthetized <jats:italic>R\u2010<\/jats:italic>praziquantel batches and on commercial, combination tablets containing racemic mixture of the drug.<\/jats:p>","DOI":"10.1002\/elps.201600492","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T09:25:25Z","timestamp":1487669125000},"page":"1886-1894","source":"Crossref","is-referenced-by-count":15,"title":["Validated capillary electrophoretic method for the enantiomeric quality control of <i>R<\/i>\u2010praziquantel"],"prefix":"10.1002","volume":"38","author":[{"given":"Zolt\u00e1n\u2010Istv\u00e1n","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy University of Medicine and Pharmacy of T\u00eergu Mure\u0219  T\u00eergu Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Medicine and Pharmacy of T\u00eergu Mure\u0219  T\u00eergu Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Sz\u0151cs","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Ludmerczki","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Pharmacy Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela\u2010Lucia","family":"Muntean","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Medicine and Pharmacy of T\u00eergu Mure\u0219  T\u00eergu Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Nosz\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerg\u0151","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.27"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.16"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.09.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000357"},{"key":"e_1_2_8_8_1","first-page":"935","volume":"99","author":"Liu Y. 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