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In this study, six homochiral metal\u2010organic frameworks constructed from Zn<jats:sup>2+<\/jats:sup> or Co<jats:sup>2+<\/jats:sup> ions and various enantiopure amino acid (L\u2010tyrosine, L\u2010histidine, L\u2010tryptophan and L\u2010glutamic acid), namely [Zn(L\u2010tyr)]<jats:sub>n<\/jats:sub>(L\u2010tyrZn), [Zn<jats:sub>4<\/jats:sub>(btc)<jats:sub>2<\/jats:sub>(Hbtc)(L\u2010His)<jats:sub>2<\/jats:sub>(H<jats:sub>2<\/jats:sub>O)<jats:sub>4<\/jats:sub>]\u00b71.5H<jats:sub>2<\/jats:sub>O, {[Zn<jats:sub>2<\/jats:sub>(L\u2010trp)<jats:sub>2<\/jats:sub>(bpe)<jats:sub>2<\/jats:sub>(H<jats:sub>2<\/jats:sub>O)<jats:sub>2<\/jats:sub>]\u00b72H<jats:sub>2<\/jats:sub>O\u00b72NO<jats:sub>3<\/jats:sub>}<jats:sub>n<\/jats:sub>, [Co<jats:sub>2<\/jats:sub>(L\u2010Trp)(INT)<jats:sub>2<\/jats:sub>(H<jats:sub>2<\/jats:sub>O)<jats:sub>2<\/jats:sub>(ClO<jats:sub>4<\/jats:sub>)], [Co<jats:sub>2<\/jats:sub>(sdba)((L\u2010Trp)<jats:sub>2<\/jats:sub>] and [Co(L\u2010Glu)(H<jats:sub>2<\/jats:sub>O)\u00b7H<jats:sub>2<\/jats:sub>O]<jats:sub>\u221e<\/jats:sub>, were synthesized according to the methods previously reported in the literature. The six homochiral MOFs were explored as the chiral stationary phases for high\u2010performance liquid chromatographic separation of enantiomers using hexane\/isopropanol or hexane\/dichloromethane as mobile phase. Various types of enantiomers such as alcohols, amines, ketones, ethers, organic acids, etc. can be resolved on these homochiral MOF columns. The results revealed that the enantioseletivities of homochiral MOFs based on amino acids as chiral bridging ligands used as stationary phases are practical in HPLC.<\/jats:p>","DOI":"10.1002\/elps.201700122","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T08:53:02Z","timestamp":1499244782000},"page":"2513-2520","source":"Crossref","is-referenced-by-count":69,"title":["Homochiral metal\u2010organic frameworks based on amino acid ligands for HPLC separation of enantiomers"],"prefix":"10.1002","volume":"38","author":[{"given":"Jun\u2010Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry Yunnan Normal University  Kunming P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Yu","family":"Nong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yunnan Normal University  Kunming P.R. 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