{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:28:31Z","timestamp":1776446911160,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enantioseparation of twelve pairs of structurally related 1\u2010aryl\u20101\u2010indanone derivatives was studied in the normal\u2010phase mode using three different polysaccharide\u2010type chiral stationary phases, namely Chiralpak IB, Chiralpak IC, and Chiralpak ID. <jats:italic>n<\/jats:italic>\u2010Hexane\/2\u2010propanol and <jats:italic>n<\/jats:italic>\u2010hexane\/ethanol were employed as mobile phases. Among all the investigated chiral columns, Chiralpak IC exhibited the most universal and the best enantioseparation ability toward all the racemates, particularly with the mobile phase composed of <jats:italic>n<\/jats:italic>\u2010hexane\/2\u2010propanol (90\/10, v\/v). Then the effects of column temperature on retention and enantioselectivity were examined in the range of 25\u201340\u00b0C. Satisfactory enantioseparation was obtained at ambient temperature. The natural logarithm of retention and separation factors (ln <jats:italic>k<\/jats:italic> and ln <jats:italic>\u03b1<\/jats:italic>) versus the reciprocal of absolute temperature (1\/<jats:italic>T<\/jats:italic>) (Van't Hoff plots) were found to be linear for all racemates, indicating that the retention and separation mechanisms were independent of temperature in the range investigated. Then, the thermodynamic parameters (\u0394\u0394<jats:italic>H<\/jats:italic>\u00b0, \u0394\u0394<jats:italic>S<\/jats:italic>\u00b0, and \u0394\u0394<jats:italic>G<\/jats:italic>\u00b0) were calculated from Van't Hoff plots. These values indicated that the solute transfer from the mobile to stationary phase was enthalpically favorable, and the process of enantioseparation was mainly enthalpy controlled. At last, the impact of small changes in molecular structures of the tested 1\u2010indanone derivatives on enantioseparation was also discussed.<\/jats:p>","DOI":"10.1002\/elps.201800194","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T03:03:35Z","timestamp":1530068615000},"page":"2398-2405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Enantioselective separation of twelve pairs of enantiomers on polysaccharide\u2010based chiral stationary phases and thermodynamic analysis of separation mechanism"],"prefix":"10.1002","volume":"39","author":[{"given":"Bolin","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province P. R. 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