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By varying the amount of acidic S\u2010\u03b2\u2010CD in the LE composed of 3\u2010morpholino\u20102\u2010hydroxypropanesulfonic acid and the chiral selector, and employing glycylglycine as terminating electrolyte (TE), inverse cationic ITP provides systems in which either both enantiomers, only the enantiomer with weaker complexation, or none of the two enantiomers form cationic ITP zones. For the configuration studied, the data reveal that only S\u2010methadone migrates isotachophoretically when the S\u2010\u03b2\u2010CD concentration in the LE is between about 0.484 and 1.113\u00a0mM. Under these conditions, R\u2010methadone migrates zone electrophoretically in the TE. An S\u2010\u03b2\u2010CD concentration between about 0.070 and 0.484\u00a0mM results in both S\u2010 and R\u2010methadone forming ITP zones. With &gt;1.113\u00a0mM and &lt; about 0.050\u00a0mM of S\u2010\u03b2\u2010CD in the LE both enantiomers are migrating within the TE and LE, respectively. Chiral inverse cationic ITP with acidic S\u2010\u03b2\u2010CD in the LE is demonstrated to permit selective ITP trapping and concentration of the less interacting enantiomer of a weak base.<\/jats:p>","DOI":"10.1002\/elps.201800387","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T05:00:24Z","timestamp":1539320424000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inverse cationic ITP for separation of methadone enantiomers with sulfated \u03b2\u2010cyclodextrin as chiral selector"],"prefix":"10.1002","volume":"40","author":[{"given":"Saara","family":"Mikkonen","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Laboratory Institute for Infectious Diseases University of Bern  Bern Switzerland"},{"name":"Division of Applied Physical Chemistry Department of Chemistry KTH Royal Institute of Technology  Stockholm 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