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In this work, for the first time, cyclohexane\u20101,3\u2010dione (CHD) was used as a derivatizing reagent aiming aldehyde (formaldehyde, acetaldehyde, propionaldehyde, and valeraldehyde) analysis by MEKC\u2010DAD. The optimized separation of the derivates was performed using a voltage program (+20\u00a0kV, 0\u201315\u00a0min.; +23\u00a0kV, 15\u201317\u00a0min.) at a temperature of 26\u00b0C, and using as the running buffer a mixture containing 100\u00a0mmol\/L of sodium dodecyl sulfate and 29\u00a0mmol\/L of sodium tetraborate at pH 9.2, with maximum absorbance at 260\u00a0nm. CHD was compared with two other derivatizing agents: 3\u2010methyl\u20102\u2010benzothiazolinone hydrazone and phenylhydrazine\u20104\u2010sulfonic acid. The CHD\u2010aldehyde derivatives were also characterized by LC\u2010MS. The calibration curves for all aldehydes had <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> above 0.999 and LODs ranged from 0.01 to 0.7\u00a0mg\/L. The optimized methodology was applied in sugar cane brandy (cacha\u00e7a) samples successfully. CHD showed to be an alternative derivatization reagent due to its stability, aqueous solubility, high selectivity and sensitivity, reduced impurities, and simple preparation steps.<\/jats:p>","DOI":"10.1002\/elps.201900171","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:19:46Z","timestamp":1567210786000},"page":"2929-2935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cyclohexane\u20101,3\u2010dione as a derivatizing agent for the analysis of aldehydes by micelar electrokinetic chromatography with diode array detection"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-0089","authenticated-orcid":false,"given":"Tiago Augusto","family":"Donegatti","sequence":"first","affiliation":[{"name":"Departamento de F\u00edsica Qu\u00edmica e Matem\u00e1tica Universidade Federal de S\u00e3o Carlos \u2010 UFSCar  Sorocaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-5647","authenticated-orcid":false,"given":"Alnilan","family":"Lobato","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-656X","authenticated-orcid":false,"given":"Lu\u00eds","family":"Moreira Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-9862","authenticated-orcid":false,"given":"Elisabete","family":"Alves Pereira","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica Qu\u00edmica e Matem\u00e1tica Universidade Federal de S\u00e3o Carlos \u2010 UFSCar  Sorocaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2015.31.3.273"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-013-9787-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.08.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22050811"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01741-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-015-0183-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/jaoac\/82.6.1562","volume":"82","author":"Pereira E. 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