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Several approaches have been proposed to address poor sensitivity in \u03bcPADs, but they frequently require bulky equipment for power and\/or read\u2010outs. Universal serial buses (USB) are an attractive alternative to less portable power sources and are currently available in many common electronic devices. Here, USB\u2010powered \u03bcPADs (USB \u03bcPADs) are proposed as a fusion of both technologies to improve performance without adding instrumental complexity. Two ITP USB \u03bcPADs were developed, both powered by a 5\u00a0V potential provided through standard USB ports. The first device was fabricated using the origami approach. Its operation was analyzed experimentally and numerically, yielding a two\u2010order\u2010of\u2010magnitude sample focusing in 15\u00a0min. The second ITP USB \u03bcPAD is a novel design, which was numerically prototyped with the aim of handling larger sample volumes. The reservoirs were moved away from the ITP channel and capillary action was used to drive the sample and electrolytes to the separation zone, predicting 25\u2010fold sample focusing in 10\u00a0min. USB \u03bcPADs are expected to be adopted by minimally\u2010trained personnel in sensitive areas like resource\u2010limited settings, the point\u2010of\u2010care and in emergencies.<\/jats:p>","DOI":"10.1002\/elps.201900273","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T06:44:30Z","timestamp":1572677070000},"page":"562-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["USB powered microfluidic paper\u2010based analytical devices"],"prefix":"10.1002","volume":"41","author":[{"given":"Federico","family":"Schaumburg","sequence":"first","affiliation":[{"name":"INTEC (Universidad Nacional del Litoral \u2013 CONICET)  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-698X","authenticated-orcid":false,"given":"Pablo A.","family":"Kler","sequence":"additional","affiliation":[{"name":"CIMEC (Universidad Nacional del Litoral \u2013 CONICET)  Santa Fe Argentina"},{"name":"Departamento de Ingenier\u00eda en Sistemas de Informaci\u00f3n FRSF\u2010UTN  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody S.","family":"Carrell","sequence":"additional","affiliation":[{"name":"Department of Chemistry Colorado State University  Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-6738","authenticated-orcid":false,"given":"Claudio L. 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