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Herein, we presented a method to employ high\u2010density silica microbeads (SiO<jats:sub>2<\/jats:sub> MBs) for capturing fetal nucleated red blood cells (fnRBCs) in maternal peripheral blood, and we detected the ABO genotype of the fetus using these captured cells. We evaluated 52 patients using the SiO<jats:sub>2<\/jats:sub> MBs. Among 26 pregnant women with type O blood, 8 (30.8%) of the fetuses had type A blood, 5 (19.2%) had type B blood, and 13 (50%) had type O blood. SRY genes were detected in all 27 male fetuses. This study represents a simple and effective method for noninvasive prenatal detection of the fetal ABO genotype. We believe that this method has great potential for noninvasive prenatal testing of the fetal Rh blood group and other fetal diseases as well.<\/jats:p>","DOI":"10.1002\/elps.201900292","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T04:38:44Z","timestamp":1575434324000},"page":"966-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Silica microbeads capture fetal nucleated red blood cells for noninvasive prenatal testing of fetal ABO genotype"],"prefix":"10.1002","volume":"41","author":[{"given":"Lin","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan Hubei P. R. China"},{"name":"Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health  Wuhan Hubei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\u2010 and Nano\u2010structures of Ministry of Education School of Physics and Technology Wuhan University  Wuhan Hubei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\u2010 and Nano\u2010structures of Ministry of Education School of Physics and Technology Wuhan University  Wuhan Hubei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan Hubei P. R. China"},{"name":"Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health  Wuhan Hubei P. R. 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