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In this work, capillary electrophoresis with capacitively coupled contactless conductivity detector was applied for the analysis of bicarbonate, phosphate, and another inorganic (chloride, nitrite, nitrate, sulfate, thiocyanate) and organic anions (acetate, butyrate) to evaluate their levels in saliva. The background electrolytes of different composition and pH between 6.02\u20139.41 were assessed for the bicarbonate and phosphate determination by comparison of the real analyses of a model solution with the simulation by PeakMaster software. The optimized background electrolyte was composed of 10\u00a0mM 2\u2010(N\u2010morpholino)ethanesulfonic acid, 20\u00a0mM arginine, and 30\u00a0\u00b5M cetyltrimethylammonium bromide, pH 8.95. Using this BGE, the anion levels were compared in saliva from 20 patients suffering from gastroesophageal reflux disease (GERD) and saliva from 12 healthy subjects. Bicarbonate levels were significantly elevated in saliva from GERD patients suggesting the possible applicability of bicarbonate as a biomarker in non\u2010invasive diagnostics of GERD by CE\u2010C<jats:sup>4<\/jats:sup>D.<\/jats:p>","DOI":"10.1002\/elps.201900319","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T02:44:50Z","timestamp":1572835490000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Analysis of bicarbonate, phosphate and other anions in saliva by capillary electrophoresis with capacitively coupled contactless conductivity detection in diagnostics of gastroesophageal reflux disease"],"prefix":"10.1002","volume":"41","author":[{"given":"V\u011bra","family":"Dosed\u011blov\u00e1","sequence":"first","affiliation":[{"name":"Department of Bioanalytical Instrumentation CEITEC Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavol","family":"\u010eur\u010d","sequence":"additional","affiliation":[{"name":"Department of Bioanalytical Instrumentation CEITEC Masaryk University  Brno Czech Republic"},{"name":"Department of Chemistry Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Dolina","sequence":"additional","affiliation":[{"name":"Department of Internal Gastroenterology Faculty Hospital Brno Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160tefan","family":"Kone\u010dn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Internal Gastroenterology Faculty Hospital Brno Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-7350","authenticated-orcid":false,"given":"Franti\u0161ek","family":"Foret","sequence":"additional","affiliation":[{"name":"Department of Bioanalytical Instrumentation CEITEC Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-5570","authenticated-orcid":false,"given":"Petr","family":"Kub\u00e1\u0148","sequence":"additional","affiliation":[{"name":"Department of Bioanalytical Instrumentation CEITEC Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-9-3-72"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.153767"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21929"},{"key":"e_1_2_8_5_1","first-page":"248","volume":"53","author":"Kadashetti V.","year":"2015","journal-title":"Rom. 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