{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T01:18:33Z","timestamp":1782004713446,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20141353"],"award-info":[{"award-number":["BK20141353"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors describe a synergistic system for nanoparticle based chiral separation. It is based on the use of a conventional chiral selector hydroxyproyl\u2010\u03b2\u2010cyclodextrin and a kind of gold nanoparticle functionalized with D\u2010penicillamine as an additive. This nanomaterial displays a synergistic effect on the efficiency of the enantioseparation of the chiral drugs amlodipine, tropicamide, and ofloxacin. A comparative study on the enantioseparation capability of three separation systems, viz. (a) single hydroxyproyl\u2010\u03b2\u2010cyclodextrin system, (b) achiral citrate capped gold nanoparticle\/ hydroxyproyl\u2010\u03b2\u2010cyclodextrin system, and (c) chiral D\u2010penicillamine functionalized gold nanoparticle\/ hydroxyproyl\u2010\u03b2\u2010cyclodextrin system was performed. The results show that the D\u2010penicillamine functionalized gold nanoparticle\/hydroxyproyl\u2010\u03b2\u2010cyclodextrin synergistic system has remarkable superiority. The effects of concentrations of D\u2010penicillamine functionalized gold nanoparticle and hydroxyproyl\u2010\u03b2\u2010cyclodextrin, of buffer pH value and concentration, and of applied voltage on the performance of enantioseparation were investigated.<\/jats:p>","DOI":"10.1002\/elps.201900369","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T06:27:50Z","timestamp":1584426470000},"page":"1060-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of the synergistic effect with chiral D\u2010penicillamine functionalized gold nanoparticle as an additive for enantiomeric separation in capillary electrophoresis"],"prefix":"10.1002","volume":"41","author":[{"given":"Zijie","family":"Feng","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) China Pharmaceutical University  Nanjing P. R. 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