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We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, stability against pH, temperature, UV light, gamma radiation, and susceptibility to various chemical agents including solvents and detergents. Possible inactivation, downstream, and formulation conditions are given including suitable buffers and some first ideas for quality\u2010control methods. This information supports vaccine development and discussion with competent authorities during vaccine approval and is certainly related to drug\u2010targeting strategies and hygienics. Several instructive tables are given, including the p<jats:italic>I<\/jats:italic> and grand average of hydropathicity (GRAVY) of SARS\u2010CoV\u20101 and \u20102 proteins in comparison. SARS\u2010CoV\u20101 and SARS\u2010CoV\u20102 are similar in many regards, so information can often be derived. Both are unusually stable, but sensitive at their lipophilic membranes. However, since seemingly small differences can have strong effects, for example, on immunologically relevant epitope settings, unevaluated knowledge transfer from SARS\u2010CoV\u20101 to SARS\u2010CoV\u20102 cannot be advised. Published knowledge regarding downstream processes, formulations and quality assuring methods is, as yet, limited. However, standard approaches employed for other viruses and vaccines seem to be feasible including virus inactivation, centrifugation conditions, and the use of adjuvants.<\/jats:p>","DOI":"10.1002\/elps.202000121","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T10:53:27Z","timestamp":1590749607000},"page":"1137-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Physicochemical properties of SARS\u2010CoV\u20102 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control"],"prefix":"10.1002","volume":"41","author":[{"given":"Christin","family":"Scheller","sequence":"first","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finja","family":"Krebs","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Minkner","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Astner","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gil\u2010Moles","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-0612","authenticated-orcid":false,"given":"Hermann","family":"W\u00e4tzig","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00073-5"},{"key":"e_1_2_14_3_1","author":"Aryal S.","year":"2019","journal-title":"Online microbiology notes: Classification of virus"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7269"},{"key":"e_1_2_14_6_1","author":"Park T.","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_14_7_1","first-page":"10642","author":"Srivastava A. 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