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A background electrolyte comprising three cyclodextrins was found to successfully separate the eight isomers. First an anionic cyclodextrin, the SBE\u2010\u03b2\u2010CD, was selected to allow the chiral separation of our neutral compound and partial resolutions of the eight isomers were obtained. Then, the effects of different parameters such as the nature and concentration of the other cyclodextrins added and pH of the buffer were examined. Finally, a triple CD\u2010system consisted of 15 mM\u00a0SBE\u2010\u03b2\u2010CD plus 15 mM\u00a0\u03b3\u2010CD and 40 mM\u00a0HP\u2010\u03b3\u2010CD in a 50\u00a0mM borate background electrolyte at pH 10, was found to successfully separate the eight isomers. Last, the selectivity and limits of detection and quantification were evaluated for this optimized method.<\/jats:p>","DOI":"10.1002\/elps.202000342","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T03:03:41Z","timestamp":1614567821000},"page":"1810-1817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrophoretic separation of multiple chiral center analyte with a three cyclodextrins mixture"],"prefix":"10.1002","volume":"42","author":[{"given":"Zuo","family":"La","sequence":"first","affiliation":[{"name":"Univ. Lille Inserm, Institut Pasteur de Lille  U1167 \u2013 Risk factors and molecular determinants of aging\u2010related diseases Lille F\u201059000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Danel","sequence":"additional","affiliation":[{"name":"Univ. 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