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In this work, a porous layer open\u2010tubular (PLOT) column with stationary phase of styrene and itaconic acid\u2010copolymerized polymer was developed. Thermal\u2010initiated polymerization method with strategies like controlling the ratio of reaction reagents to solvents and reaction time, confinement by the narrow inner diameter of capillary were used for preparing the stationary phase with uniform structure and relatively thick layer. Due to the high separation efficiency and capacity, the PLOT column was used for capillary electrochromatography (CEC) separation of multiple groups of analytes like alkylbenzenes, phenyl amines, phenols, vanillins, and sulfonamides with theoretical plates (N) up to 1,54,845 N\/m. In addition, due to high permeability of the CEC column and large electroosmotic flow mobility generated by abundant carboxyl groups in the coating material, the PLOT\u2010CEC column was successfully coupled with mass spectrometry (MS) through a sheath flow interface. The developed PLOT\u2010CEC\u2010MS method was used for the analysis of antiseptics like parabens and herbicides like pyridines.<\/jats:p>","DOI":"10.1002\/elps.202100148","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T13:54:22Z","timestamp":1631195662000},"page":"2664-2671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Porous layer open\u2010tubular column with styrene and itaconic acid\u2010copolymerized polymer as stationary phase for capillary electrochromatography\u2013mass spectrometry"],"prefix":"10.1002","volume":"42","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministryof Education Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences  Wuhan P. R. 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