{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:36Z","timestamp":1786977816816,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The detection of cancer biomarkers is of great significance for the early screening of cancer. Detecting the content of sarcosine in blood or urine has been considered to provide a basis for the diagnosis of prostate cancer. However, it still lacks simple, high\u2010precision and wide\u2010ranging sarcosine detection methods. In this work, a Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    \/Pt\u2013Pd nanocomposite with high stability and excellent electrochemical performance has been synthesized by a facile one\u2010step alcohol reduction and then used on a glassy carbon electrode (GCE) with sarcosine oxidase (SO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    ) to form a sarcosine biosensor (GCE\/Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    \/Pt\u2013Pd\/SO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    ). The prominent electrocatalytic activity and biocompatibility of Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    \/Pt\u2013Pd enable the SO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    to be highly active and sensitive to sarcosine. Under the optimized conditions, the prepared biosensor has a wide linear detection range to sarcosine from 1 to 1000\u00a0\u00b5M with a low limit of detection of 0.16\u00a0\u00b5M (S\/N\u00a0=\u00a03) and a sensitivity of 84.1\u00a0\u00b5A\/mM\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    . Besides, the reliable response in serum samples shows its potential in the early diagnosis of prostate cancer. More importantly, the successful construction and application of the amperometric biosensor based on Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    \/Pt\u2013Pd will provide a meaningful reference for detecting other cancer biomarkers.\n                  <\/jats:p>","DOI":"10.1002\/elps.202100218","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T09:31:54Z","timestamp":1658309514000},"page":"2033-2043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Ti\n                    <sub>3<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    T\n                    <i>\n                      <sub>X<\/sub>\n                    <\/i>\n                    \/Pt\u2013Pd based amperometric biosensor for sensitive cancer biomarker detection"],"prefix":"10.1002","volume":"43","author":[{"given":"Bin","family":"Ran","sequence":"first","affiliation":[{"name":"School of Science Harbin Institute of Technology, Shenzhen  Shenzhen P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozhan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology, Shenzhen  Shenzhen P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology, Shenzhen  Shenzhen P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minbo","family":"Lan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai P. 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