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In this study, the conditioned place preference (CPP) of MA addiction in adult male mice was established to detect changes in gut microbiota profiles after LBP treatment through 16S rRNA gene sequencing. Our results found that LBP administration could alleviate MA\u2010induced CPP and hyperactivity. Interestingly, LBP improved MA\u2010induced gut microbiota dysbiosis by increasing some beneficial autochthonous genus abundances, such as <jats:italic>Allobaculum<\/jats:italic>, <jats:italic>Gordonibacter<\/jats:italic>, and <jats:italic>Ileibacterium<\/jats:italic>. MA exposure induced the co\u2010occurrence network of intestinal microbiota to become weaker and more unstable when compared with the control group, while LBP changed the above effects when compared with the MA group. Bacterial gene function prediction showed that amphetamine addiction, cocaine addiction, and short\u2010chain fatty acid metabolism were enriched. These findings reveal that LBP might regulate MA\u2010induced gut microbiota and behavior changes, which showed potential therapeutic applicability in treating MA addiction by regulating the gut microbiota.<\/jats:p>","DOI":"10.1002\/elps.202300190","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:20:43Z","timestamp":1711412443000},"page":"958-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Lycium barbarum<\/i> polysaccharide mitigated methamphetamine addiction and altered methamphetamine\u2010induced gut microbiota dysbiosis"],"prefix":"10.1002","volume":"45","author":[{"given":"Jingshen","family":"Zhuang","sequence":"first","affiliation":[{"name":"Division of Spine Surgery Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou P. R. 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