{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:57:08Z","timestamp":1791377828011,"version":"4.3.2"},"reference-count":56,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To gain a deeper understanding of the current status of research on Traditional Chinese Medicine (TCM) and nanoparticles, we conducted a bibliometric study. We conducted a literature search in the Web of Science (WOS) for publications related to TCM and nanoparticles from 1992 to 2023. The data, including countries of publication, research institutions, journals, citations, and keywords, were analyzed using the Bibliometrix R\u20104.0 software package. We performed an analysis to identify the co\u2010occurrence of keywords in the documents including their titles and abstracts. From 2005 to 2023, a total of 309 publications were included, with an average annual growth rate of 4.25%. The majority of these publications were published in Q1 journals (72, 47.06%) and Q2 journals (45, 29.41%). Among the 309 publications, 22 articles (7.12%) had an impact factor greater than 10, while 78 articles (25.24%) had an impact factor greater than 5. The analysis of international collaboration networks revealed limited international cooperation, with most collaborations occurring between institutions in China, the United States, and Australia. These 309 publications involved a total of 438 research institutions, with Chinese research institutions being the most prolific contributors. In this study, a total of 309 publications were included, comprising 1142 author keywords and 1175 keywords plus. Factor analysis of the 1175 keywords plus revealed that they could be grouped into five categories: one category included terms such as \u201coxide\u201d and \u201czinc,\u201d another category included terms like \u201clipid\u201d and \u201cacid,\u201d a third category included terms such as \u201cimprove\u201d and \u201cenhance,\u201d a fourth category included terms like \u201csilica\u201d and \u201cmesoporous,\u201d and the fifth category included terms like \u201cPLGA\u201d and \u201cimmune.\u201d Research on nanoparticles in TCM has been gradually gaining popularity. Currently, most of the research in this field is conducted in China, with limited international collaboration. The majority of TCM nanoparticle research focuses on individual herbal compounds, while research on nanoparticle formulations of traditional herbal prescriptions is relatively scarce.<\/jats:p>","DOI":"10.1002\/elps.202300207","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:25:47Z","timestamp":1698827147000},"page":"288-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-132X","authenticated-orcid":false,"given":"Dayuan","family":"Zhong","sequence":"first","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"},{"name":"Institute of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixian","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"},{"name":"Post\u2010graduate Institute Guangzhou University of Chinese Medicine  Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"},{"name":"Institute of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"},{"name":"Institute of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huier","family":"Xiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"},{"name":"Institute of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine Guangzhou University of Chinese Medicine  Foshan Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20231067"},{"issue":"19","key":"e_1_2_11_3_1","first-page":"5807","article-title":"Study on the production process of traditional Chinese medicine compound preparation based on the characteristics of traditional Chinese medicine compound preparation","volume":"52","author":"Chen X","year":"2021","journal-title":"Chin Tradit Herbal Drugs"},{"issue":"6","key":"e_1_2_11_4_1","first-page":"1099","article-title":"Research progress on pharmacological effects of compatibility of nature flavor and components of traditional Chinese medicine compound","volume":"43","author":"Lv CY","year":"2018","journal-title":"Chin J Chin Materia Medica"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1365394"},{"key":"e_1_2_11_6_1","first-page":"1","article-title":"Progress in experimental and clinical research of the diabetic retinopathy treatment using traditional Chinese medicine","volume":"4","author":"Xu ZH","year":"2018","journal-title":"Am J Chin Med"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2018-0031"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.06.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15828"},{"issue":"04","key":"e_1_2_11_10_1","first-page":"1156","article-title":"Research progress of targeted preparations of traditional Chinese medicine","volume":"52","author":"Jiang YQ","year":"2021","journal-title":"Chin Tradit Herb Drugs"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109128"},{"issue":"04","key":"e_1_2_11_12_1","first-page":"588","article-title":"The development of nano\u2010Chinese medicine and the modernization of Chinese medicine","volume":"18","author":"Tian L","year":"2023","journal-title":"World Chin Med"},{"issue":"7","key":"e_1_2_11_13_1","first-page":"1800","article-title":"The application of the concept of \u201ccombination of medicine and auxiliary\u201d in the design of drug delivery system of traditional Chinese medicine preparation","volume":"48","author":"Hu HQ","year":"2023","journal-title":"Chin J Chin Materia Medica"},{"issue":"9","key":"e_1_2_11_14_1","first-page":"1808","article-title":"Analysis of the influencing factors of the quality of traditional Chinese medicine preparations","volume":"42","author":"Liu Y","year":"2017","journal-title":"Chin J Chin Materia Medica"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c05217"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-1977-1-221"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1360\/SSV-2019-0213"},{"issue":"12","key":"e_1_2_11_18_1","first-page":"104","article-title":"Research on the basic problems of traditional Chinese medicine based on nanotechnology","volume":"28","author":"Yang XL","year":"2000","journal-title":"J Huazhong Univ Sci Technol (Nat Sci Ed)"},{"issue":"08","key":"e_1_2_11_19_1","article-title":"Application progress of nanotechnology in traditional Chinese medicine","volume":"17","author":"Yang H","year":"2022","journal-title":"World J Integr Tradit West Med"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2017.08.007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11120"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200500015"},{"key":"e_1_2_11_24_1","first-page":"11","article-title":"The number of Chinese students studying in the United States is 55000 less","volume":"003","author":"Wang Y","year":"2021","journal-title":"Huanqiu Shibao"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-19-14"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122167"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08870"},{"issue":"10","key":"e_1_2_11_28_1","first-page":"1061","article-title":"Tanshinone IIA\u2010loaded nanoparticle and neural stem cell therapy enhances recovery in a pig ischemic stroke model stem cells","volume":"11","author":"Kaiser EE","year":"2022","journal-title":"Transl Med"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b10398"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2021.106821"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10060623"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/12298093.2019.1625175"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.10.1949"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2514-2517.2000"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13030437"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076814"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01522"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.01.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn404083m"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.08.027"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39279-z"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206955"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.03.013"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn100448z"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.03.010"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06529-y"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40291"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.01.035"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.01.222"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR08292G"},{"issue":"01","key":"e_1_2_11_51_1","first-page":"96","article-title":"Research progress of preparation methods of nano\u2010Chinese medicine","volume":"37","author":"Meng Z","year":"2022","journal-title":"West Chin J Pharm Sci"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S161237"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112461"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119907"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01052"},{"issue":"04","key":"e_1_2_11_56_1","first-page":"60","article-title":"Research progress of nano preparation of traditional Chinese medicine","volume":"11","author":"Zheng XT","year":"2020","journal-title":"Pharm Chin Materia Medica"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.739644"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.202300207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:38:26Z","timestamp":1760546306000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.202300207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":56,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/elps.202300207"],"URL":"https:\/\/doi.org\/10.1002\/elps.202300207","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}