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The study explores various factors influencing the separation efficiency, including CD concentration, organic modifier content, voltage application, and buffer pH. Optimal conditions were identified as a 100 mM phosphate buffer (pH 6.0) with 34\u00a0mg\u00a0mL<jats:sup>\u20131<\/jats:sup> S\u2010\u03b2\u2010CD and 40% (v\/v) methanol. The method demonstrated excellent linearity in calibration curves, with coefficients of determination exceeding 0.99 for each enantiomer. Precision studies revealed good intra\u2010 and inter\u2010day precision for migration times and peak areas. The limits of detection and quantification for the analytes were within the ranges of 5.9\u201311.4 and 18\u201334.6\u00a0\u00b5mol\u00a0L<jats:sup>\u20131<\/jats:sup>, respectively. Overall, the developed CE method offers a robust and precise approach for the chiral separation of H1\u2010antihistamine drugs, holding promise for pharmaceutical applications.<\/jats:p>","DOI":"10.1002\/elps.202300271","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T02:19:30Z","timestamp":1712283570000},"page":"1479-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated \u03b2\u2010cyclodextrin"],"prefix":"10.1002","volume":"45","author":[{"given":"Navid","family":"Niaei","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soodabeh","family":"Hassanpour","sequence":"additional","affiliation":[{"name":"Department of 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