{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:55:27Z","timestamp":1787504127305,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A green method by capillary electrophoresis (CE) is described for the first time for the determination of dapagliflozin (DAPA), an oral hypoglycemic drug approved for the treatment of Type 2 diabetes mellitus. The effects of different analytical conditions were evaluated, including the concentration and pH of the background electrolyte (BGE), sample injection time, applied voltage, as well as capillary temperature. The method was validated by establishing the linearity, intra\u2010 and interday precisions (relative standard deviation, RSD%), accuracy, and robustness. The analytical procedure was linear in the range of 50\u2013175\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0&gt;\u00a00.999), with the limit of detection (LOD) and limit of quantitation (LOQ) of 6.2 and 18.8\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. Precision had an intraday RSD of 2.55% and an interday RSD of 2.52%. The average recovery rates for the pharmaceutical samples ranged from 101.22% to 104.63%, with an RSD of 0.88%. Additionally, the CE method was compared to a high\u2010performance liquid chromatography (HPLC) method for quantifying DAPA, and their green profiles were assessed by the Analytical Greenness Metric (AGREE), confirming the eco\u2010friendliness of the CE technique. The methodology is suitable for determining DAPA in tablets; CE provides a greener alternative due to low\u2010cost analysis using fewer organic solvents and minimizing waste generation.\n                  <\/jats:p>","DOI":"10.1002\/elps.70042","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:25:06Z","timestamp":1759065906000},"page":"1684-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a Green Capillary Electrophoresis Method for Determining and Quality Control of Dapagliflozin: An Oral Hypoglycemic Agent"],"prefix":"10.1002","volume":"46","author":[{"given":"L\u00edvia Maronesi","family":"Bueno","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Quality Control Federal University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoelly Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Quality Control Federal University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mohr","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Quality Control Federal University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia Neves","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Chemistry Institute Federal University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Steppe","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Quality Control Federal University of Rio Grande Do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01829.x"},{"key":"e_1_2_9_3_1","volume-title":"Diabetes","author":"World Health Organization","year":"2025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2024.100167"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.807548"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2019.1667820"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2018.46547"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202400313"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.22456\/2527-2616.128661"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/2949681016666230823091112"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103111"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5384"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-025-00770-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2022.116092"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2019.1590208"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations9020025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations11120346"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26144141"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2024.342889"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2013.04.010"},{"key":"e_1_2_9_22_1","volume-title":"Handbook of Pharmaceutical Excipients","author":"Rowe R. 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