{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:45:07Z","timestamp":1777869907285,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The growing concern over drug abuse, particularly involving amphetamine\u2010type substances (ATS), has led to their monitoring in environmental waters. These chiral compounds, commonly found in river water and wastewater treatment plant (WWTP) effluents, require analytical methods capable of enantiomeric discrimination, as their enantiomers can exhibit different pharmacological and environmental behaviours. A method based on capillary electrophoresis (CE) coupled with tandem mass spectrometry (MS\/MS) was developed using a dual cyclodextrin (CD) system consisting of 0.1% 2\u2010hydroxypropyl\u2010\u03b2\u2010CD and 0.1% \u03b3\u2010CD in the background electrolyte (BGE), which enabled baseline resolution of the target enantiomers of the ATS under study. Samples were pretreated with solid\u2010phase extraction using a mixed\u2010mode cation exchange sorbent, ExtraBond SCX. Samples of 100\u00a0mL for WWTP influent and 250\u00a0mL for river water and WWTP effluent were extracted and then eluted with 5\u00a0mL of 5% NH\n                    <jats:sub>4<\/jats:sub>\n                    OH in methanol. Recoveries ranged between 40% and 67% for all amphetamines studied, with detection limits between 0.1 and 0.8\u00a0\u00b5g\/L. Analysis of environmental samples from the Ebre River and WWTPs in Reus and Tarragona (Catalonia, Spain) confirmed the presence of some of the target compounds. Both enantiomers of 3,4\u2010methylenedioxymethamphetamine (MDMA) were determined in WWTP influents and effluents, whereas\n                    <jats:italic>R<\/jats:italic>\n                    \u2010amphetamine was quantified in an influent sample. No target compounds were detected in the analysed river water samples. These findings demonstrate the potential of the developed chiral CE\u2013MS\/MS method for robust enantiomeric profiling in environmental waters, attributed to efficient separation based on differences in effective mobility (\n                    <jats:italic>\u00b5<\/jats:italic>\n                    <jats:sub>eff<\/jats:sub>\n                    ), electroosmotic flow (\n                    <jats:italic>\u00b5<\/jats:italic>\n                    <jats:sub>eo<\/jats:sub>\n                    ) and selective interactions with CD chiral selectors. The method showed moderate adherence to green analytical principles, achieving an AGREE score of 0.47. Its environmental advantages include the use of CE, minimal solvent consumption and non\u2010toxic chiral selectors, offering a more suitable alternative to more traditional LC\u2010based methods.\n                  <\/jats:p>","DOI":"10.1002\/elps.70074","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:29:08Z","timestamp":1769232548000},"page":"250-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enantioselective Determination of Amphetamine\u2010Type Stimulants in Environmental Waters Using SPE and CE\u2013MS\/MS"],"prefix":"10.1002","volume":"47","author":[{"given":"Pol","family":"Clivill\u00e9\u2010Cabr\u00e9","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Borrull","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Calull","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"World Drug Report 2023(United Nations Office on Drugs and Crime 2023) https:\/\/doi.org\/10.18356\/9789210028233.","DOI":"10.18356\/9789210028233"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"World Drug Report 2020(United Nations Office on Drugs and Crime 2020) https:\/\/doi.org\/10.18356\/c8bbbf82-en.","DOI":"10.18356\/c8bbbf82-en"},{"key":"e_1_2_8_4_1","unstructured":"Perspectives on Drugs. 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