{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:05:58Z","timestamp":1784297158652,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the chiral recognition behavior of the polysaccharide\u2011based chiral stationary phase amylose tris(3,5\u2011dimethylphenylcarbamate) (Chiralpak AD\u20113) under polar organic conditions, using a series of racemic cinnamyl 2\u2011aminoanilides differing only in the nature of their aliphatic substituents. Remarkably large differences in enantioselectivity were observed among closely related compounds, with enantioseparation factors reaching exceptionally high values (\u03b1 up to 37) when neat 2\u2011propanol was employed as the mobile phase. In contrast, replacement of 2\u2011propanol with 1\u2011propanol led to a dramatic reduction or complete loss of chiral discrimination, highlighting the crucial role of solvent structure in modulating analyte\u2013selector interactions. Analysis of retention and selectivity trends suggests that chiral recognition primarily arises from hydrogen bonding involving the anilide NH\n                    <jats:sub>2<\/jats:sub>\n                    group, combined with other interactions modulated by the aliphatic side chains. These findings emphasize how subtle structural modifications, together with mobile phase composition, can profoundly affect enantioselectivity on polysaccharide\u2011based chiral stationary phases.\n                  <\/jats:p>","DOI":"10.1002\/elps.70109","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:30:48Z","timestamp":1779193848000},"page":"613-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probing Chiral Recognition on Amylose Tris(3,5\u2010Dimethylphenylcarbamate) Using Cinnamyl 2\u2010Aminoanilides: The Subtle Impact of Aliphatic Substituents"],"prefix":"10.1002","volume":"47","author":[{"given":"Selen G\u00f6zde","family":"Kaya","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d P.le A. Moro 5 Rome Italy"},{"name":"Faculty of Pharmacy Gazi University Department of Pharmaceutical Chemistry  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Raucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d P.le A. Moro 5 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Zwergel","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d P.le A. Moro 5 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Mai","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d P.le A. Moro 5 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Valente","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d P.le A. Moro 5 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cirilli","sequence":"additional","affiliation":[{"name":"Centro Nazionale per il Controllo e la Valutazione dei Farmaci Istituto Superiore di Sanit\u00e0 Viale Regina Elena 299  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.115709"},{"key":"e_1_2_9_3_1","first-page":"159A","article-title":"Chiral HPLC With Polysaccharide Derivatives as Stationary Phases","volume":"66","author":"Okamoto Y.","year":"1994","journal-title":"Analytical Chemistry"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(00)00501\u2010X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)15213773(19980504)37:8<1020::AIDANIE1020>3.0.CO;25"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/b808881k"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja020828g"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00846"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(03)01262\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0103672"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm070006h"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp060989f"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461202"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464161"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462226"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.03.029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.07.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.339880"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2025.343771"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.09.052"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28217419"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000535"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900236b"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fntpr.2022.1086897"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23668"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2025.466622"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/elps.70109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:33:48Z","timestamp":1784295228000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/elps.70109"],"URL":"https:\/\/doi.org\/10.1002\/elps.70109","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}