{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:46Z","timestamp":1786988146363,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This work describes a novel, simple, fast, reliable, and environmentally friendly analytical method for the determination of the anti\u2010inflammatory and analgesic drug flunixin meglumine (FM) in veterinary pharmaceutical formulations. The method uses capillary electrophoresis with capacitively coupled contactless conductivity detection (CE\u2010C\n                    <jats:sup>4<\/jats:sup>\n                    D) to quantify meglumine (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylglucamine), the counterion of flunixin in FM. This approach allows the use of the less expensive and more readily available meglumine, rather than FM or flunixin, as the standard reagent. Lithium ions were used as an internal standard, and the migration time of the meglumine was 2.2\u00a0min using a capillary with a total length of 50\u00a0cm (42\u00a0cm effective) and 50\u00a0\u00b5m (i.d.), filled with a background electrolyte (BGE) composed of 2\u2010(\n                    <jats:italic>N<\/jats:italic>\n                    \u2010morpholino)ethanesulfonic acid (MES) and histidine (His), each at 20\u00a0mmol\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Good linearity was attained (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.992) in a concentration range of 100\u20132500\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The limits of detection (LOD) and quantification (LOQ) were calculated as 22.7 and 75.6\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. The accuracy of the method was assessed using recovery tests at three concentration levels, resulting in recoveries ranging from 89% to 104%. The intra\u2010 and inter\u2010day precisions ranged from 2.3% to 4.2%. The proposed CE\u2010C\n                    <jats:sup>4<\/jats:sup>\n                    D was successfully applied to determine FM in commercial veterinary formulations.\n                  <\/jats:p>","DOI":"10.1002\/elps.70114","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:50:41Z","timestamp":1779537041000},"page":"690-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Flunixin Meglumine in Veterinary Pharmaceutical Formulations by Capillary Electrophoresis With Capacitively Coupled Contactless Conductivity Detection"],"prefix":"10.1002","volume":"47","author":[{"given":"Let\u00edcia M.","family":"de Araujo","sequence":"first","affiliation":[{"name":"Institute of Chemistry Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A. Fracassi","family":"da Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"},{"name":"National Institute of Science and Technology of Bioanalytics Lauro Kubota (INCTBio\u2010LK) Institute of Chemistry Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dosil P.","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"},{"name":"National Institute of Science and Technology of Bioanalytics Lauro Kubota (INCTBio\u2010LK) Institute of Chemistry Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12212939"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3961"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11020282"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.15232\/aas.2020\u201002106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738\u2010022\u201002699\u20101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2025.124633"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826070802281802"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573412913666170918163625"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.07.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1529280"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancr.2014.12.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt120"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1061934817050124"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2321572"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2022.141457"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5296582"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9707592"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac980185g"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(01)01380\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202400217"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131858"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202300179"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20104347(96)00393\u20103"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2011.1059"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/elps.70114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:05:05Z","timestamp":1786986305000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.70114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/elps.70114"],"URL":"https:\/\/doi.org\/10.1002\/elps.70114","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}