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In large\u2010scale microchannels, off\u2010axis particle trajectories lead to significant waveform distortion and the attenuation of key characteristic features, undermining measurement precision. To address this issue, this study presents a novel signal\u2010processing framework centered on a full\u2010waveform calibration factor (CF). The CF is theoretically grounded in the exponential decay of the electric field along the vertical axis of coplanar electrodes and is derived from comprehensive waveform features rather than localized extrema, ensuring robustness against the distortions prevalent in high\u2010flow conditions. Coupled with a dedicated real\u2010time algorithm, it corrects for vertical position\u2010induced errors in particle sizing. The effectiveness of this method was validated through a combination of finite element simulation and experimental impedance measurement. 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Experimental calibration achieves a strong linear correlation () between the sensor response and measured height, confirming the method's utility for spatially resolved impedance\u00a0cytometry.<\/jats:p>","DOI":"10.1002\/elps.70132","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:42:49Z","timestamp":1784878969000},"page":"866-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Position\u2010Independent Particle Sizing in High\u2010Precision Impedance Cytometry via Full\u2010Waveform Feature Calibration"],"prefix":"10.1002","volume":"47","author":[{"given":"Junwei","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Hebei Province, School of Health Sciences and Biomedical Engineering Hebei University of Technology Tianjin 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