{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:48:21Z","timestamp":1792158501003,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study presents an affordable micellar electrokinetic chromatography (MEKC) method for the simultaneous analysis of six commonly used antiepileptic drugs: ethosuximide, phenobarbital, lamotrigine, phenytoin, carbamazepine, and diazepam. Systematic optimization of the method resulted in a running buffer containing 80\u00a0mM sodium dodecyl sulfate, 5% methanol, 2.5\u00a0mM phosphate, and 10\u00a0mM borate at pH\u00a08.7, which provided robust and reliable separation. The method demonstrated excellent precision, with migration time %RSD values below 2% for both intraday and inter\u2010day repeatability, and peak area %RSD values within acceptable limits (1.7%\u20133.7% intraday; 2.9%\u20136.3% inter\u2010day). Linearity was confirmed for all analytes, with\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    values exceeding 0.99 and residuals randomly distributed around zero. Robustness testing showed that small variations in electrophoretic conditions did not significantly affect the resolution of the critical analyte pairs, which consistently remained above 1.5. Application of the method to five antiepileptic tablet formulations obtained from the Ethiopian market demonstrated its suitability as a rapid, reliable, and cost\u2010effective screening tool. Overall, the developed MEKC method provides a practical analytical approach for antiepileptic medicines\u2019 quality assessment in resource\u2010limited settings, supporting efforts to strengthen regulatory surveillance and safeguard public health.\n                  <\/jats:p>","DOI":"10.1002\/elps.70137","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:47:08Z","timestamp":1786103228000},"page":"939-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Micellar Electrokinetic Chromatography Screening Tool for Antiepileptic Drugs"],"prefix":"10.1002","volume":"47","author":[{"given":"Hailekiros Gebretsadik","family":"Kidanemariam","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences Pharmaceutical Analysis KU Leuven\u2014University of Leuven  Leuven Belgium"},{"name":"Faculty of Pharmacy Pharmaceutical Analysis and Quality Assurance College of Health Sciences Mekelle University  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences Pharmaceutical Analysis KU Leuven\u2014University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Schepdael","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences Pharmaceutical Analysis KU Leuven\u2014University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Epilepsy(WHO 2024) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/epilepsy."},{"key":"e_1_2_10_3_1","first-page":"159","volume-title":"Neuroepidemiology. Handbook of Clinical Neurology","author":"Abramovici S.","year":"2016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2015.11.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050470"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.20093"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42494\u2010021\u201000055\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3928\/00904481\u201020150203\u201010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1662"},{"key":"e_1_2_10_10_1","unstructured":"R.CartwrightandA.Bari\u0107 The Rise of Counterfeit Pharmaceuticals in Africa ENACT Policy Brief No. 06 (ENACT 2018)."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/20523211.2024.2375267"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10081392"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.121.000994"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000172"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.116992"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c00857"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202000185"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809375-7.00005-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8964-5_6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.115453"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.07.026"},{"issue":"2","key":"e_1_2_10_22_1","first-page":"45","article-title":"Development of a Low\u2010Cost and Easy\u2010Assembly Capillary Electrophoresis System for Separation of DNA","volume":"18","author":"Li J.","year":"2024","journal-title":"Journal of Capillary Electrophoresis and Microchip Technology"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600796"},{"key":"e_1_2_10_24_1","volume-title":"Validation of Analytical Procedures Q2 (R2)","author":"ICH Guideline","year":"2022"},{"key":"e_1_2_10_25_1","unstructured":"R core team \u201cA language and environment for statistical computing (version 4.5.2)\u201d Vienna Austria R foundation for statistical computing (2025) https:\/\/www.R\u2010project.org\/ Accessed 3 August 2026."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700869"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2AY01807A"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201500411"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1556\/1326.2020.00812"},{"key":"e_1_2_10_30_1","volume-title":"United States Pharmacopeia\u2013National Formulary (USP 49\u2013NF 44)","author":"United States Pharmacopeial Convention","year":"2026"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/elps.70137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:59:19Z","timestamp":1792155559000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.70137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/elps.70137"],"URL":"https:\/\/doi.org\/10.1002\/elps.70137","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}