{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:48:18Z","timestamp":1792158498872,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interest in unsymmetrically disubstituted metallocene derivatives, originally developed for asymmetric synthesis, emerged later in medicinal chemistry. In this study, 21 novel compounds were investigated, including (i) 1,2\u2010, 1,3\u2010, and 1,\n                    <jats:italic>n<\/jats:italic>\n                    \u2032\u2010disubstituted ruthenocenes and ferrocenes; (ii) ruthenocenes and ferrocenes with central chirality; and (iii) a ruthenocene possessing both central and planar chirality, for which four stereoisomers are expected. The compounds were analyzed by normal\u2010phase mode liquid chromatography under arbitrarily selected conditions of 20\u00b0C and a flow rate of 1\u00a0mL\/min, with UV detection at 260\u00a0nm. Eight polysaccharide\u2010based chiral stationary phases were evaluated, using\n                    <jats:italic>n<\/jats:italic>\n                    \u2010heptane combined with either 20% ethanol or 2\u2010propanol as the mobile phase. In addition to coated silica gel stationary phases, including cellulose\n                    <jats:italic>tris<\/jats:italic>\n                    (3\u2010chloro\u20104\u2010methylphenylcarbamate), immobilized silica gel stationary phases, such as cellulose\n                    <jats:italic>tris<\/jats:italic>\n                    (3,5\u2010dichlorophenylcarbamate), and amylose and cellulose\n                    <jats:italic>tris<\/jats:italic>\n                    (3,5\u2010dimethylphenylcarbamate), were investigated for these derivatives. Significant differences in enantioseparation were observed depending on the molecular structure of the derivative, the nature of the stationary phase, and the type and percentage of alcohol used in the mobile phase. Notably, none of the columns tested was able to separate all isomers, regardless of whether identical or varied alcohol types and concentrations were employed.\n                  <\/jats:p>","DOI":"10.1002\/elps.70144","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:37:57Z","timestamp":1787204277000},"page":"992-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coated and Immobilized Polysaccharides\u2010Based Stationary Phases for Planar Metallocenes Enantioseparation in Liquid Chromatography"],"prefix":"10.1002","volume":"47","author":[{"given":"Florine","family":"Wartelle","sequence":"first","affiliation":[{"name":"University of Lille, Inserm, CHU De Lille, U1352\u2014BioPrev: Better Aging: From Inflammaging to Prevention  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Leblond","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU De Lille, U1352\u2014BioPrev: Better Aging: From Inflammaging to Prevention  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bonin","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU De Lille, U1352\u2014BioPrev: Better Aging: From Inflammaging to Prevention  Lille France"},{"name":"JUNIA Health &amp; Environment Laboratory of Sustainable Chemistry and Health  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-4331","authenticated-orcid":false,"given":"Alina","family":"Ghinet","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU De Lille, U1352\u2014BioPrev: Better Aging: From Inflammaging to Prevention  Lille France"},{"name":"JUNIA Health &amp; Environment Laboratory of Sustainable Chemistry and Health  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-963X","authenticated-orcid":false,"given":"Emmanuelle","family":"Lipka","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU De Lille, U1352\u2014BioPrev: Better Aging: From Inflammaging to Prevention  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Ferrocenes: Homogeneous Catalysis, Organic Synthesis, Materials Science","author":"Hayashi T.","year":"1995"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2021.03.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac199567081307"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201600983"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602482"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202200148"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcoa.2024.100147"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(02)01197\u20104"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463097"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23417"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202200205"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341725"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2024.343160"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2025.344853"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463115"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463306"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac50001a037"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20138k"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20386"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(01)88753\u20107"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/elps.70144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.70144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:59:25Z","timestamp":1792155565000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.70144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/elps.70144"],"URL":"https:\/\/doi.org\/10.1002\/elps.70144","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"2026-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}