{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:26Z","timestamp":1791276926617,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22364022"],"award-info":[{"award-number":["22364022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22564021"],"award-info":[{"award-number":["22564021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ionic covalent organic frameworks (iCOFs), as a branch of emerging organic framework materials, integrate charged functional sites with periodically ordered pore structures. Owing to their distinctive merits, including adjustable electrostatic interactions, permanent porosity, well\u2010defined pore channels, and excellent structural designability, iCOFs have aroused widespread research interest. In this study, a novel HPLC chiral stationary phase (CD\u2010COF\u2010Li@SiO\n                    <jats:sub>2<\/jats:sub>\n                    ) was prepared by an in situ growth strategy. The CD\u2010COF\u2010Li@SiO\n                    <jats:sub>2<\/jats:sub>\n                    column showed good chiral separation performance for 19 pairs of enantiomers, including alcohols, esters, ketones, organic acids, and aldehydes. Most of the analytes were baseline\u2010separated, and the resolution of some enantiomers (1\u2010(4\u2010chlorophenyl) ethanol and 2\u2010chloro\u20102\u2010phenylacetophenone) reached 3.00. Compared with CTpBD@SiO\n                    <jats:sub>2<\/jats:sub>\n                    , \u03b2\u2010CD\u2010COF@SiO\n                    <jats:sub>2<\/jats:sub>\n                    , and two widely used commercial chiral columns (Chiralpak AD\u2010H and Chiralcel OD\u2010H), it was found that the fabricated column had good chiral recognition complementarity with four chiral chromatographic columns. Furthermore, the effects of the injection mass of the analyte, column temperature, and the proportion of the mobile phase on the separation of racemates were also discussed. This column exhibited good reproducibility and stability. After hundreds of injections, the relative standard deviation (RSD) values of retention time and resolution were both below 1%. In addition, the proposed CD\u2010COF\u2010Li@SiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based HPLC method demonstrated favorable performance for quantitative analysis by using (S)\u2010ethyl mandelate as a model analyte. Accordingly, the limit of detection value of 0.38 \u00b5g\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and the limit of quantitation value of 1.26 \u00b5g\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for (S)\u2010ethyl mandelate detection were obtained. This work highlights the promising prospects of chiral iCOFs for enantioseparation in HPLC.\n                  <\/jats:p>","DOI":"10.1002\/elps.70162","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:42:29Z","timestamp":1791276149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chiral Ionic Covalent Organic Framework Core\u2010Shell Composite Material CD\u2010COF\u2010Li@SiO\n                    <sub>2<\/sub>\n                    for HPLC Enantioseparation"],"prefix":"10.1002","author":[{"given":"Chang\u2010Xiu","family":"Ma","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P.R. 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