{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:54:13Z","timestamp":1791572053317,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51805270"],"award-info":[{"award-number":["51805270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Electrophoresis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Deterministic lateral displacement (DLD), a hydrodynamic particle manipulation technology, has been extensively studied for the development of fast and efficient microfluidic chips for particle manipulation and detection. However, particles are prone to clogging in DLD chips with closely spaced pillars, which can reduce sorting efficiency. Previous studies have shown that elliptical pillars provide better separation performance than equilateral triangular pillars. In elliptical\u2010pillar DLD, a negative angle of inclination (\n                    <jats:italic>Aoi<\/jats:italic>\n                    ) reduces the particle period and facilitates efficient isolation of large particles, whereas a positive\n                    <jats:italic>Aoi<\/jats:italic>\n                    decreases the critical diameter, thereby improving the sorting of smaller particles. On the basis of these findings, we designed a two\u2010stage DLD microfluidic chip with inclined elliptical\u2010pillar arrays, using an\n                    <jats:italic>Aoi<\/jats:italic>\n                    of \u221245\u00b0 in the first stage and 45\u00b0 in the second stage. The combination of negative and positive\n                    <jats:italic>Aoi<\/jats:italic>\n                    values enhanced the isolation of large particles, improved the purification of medium\u2010 and small\u2010sized particles, and reduced the risk of clogging. This design provides a practical approach for improving the separation and purification performance of DLD devices and offers potential for efficient multi\u2010size particle separation.\n                  <\/jats:p>","DOI":"10.1002\/elps.70164","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:21:49Z","timestamp":1791570109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Highly Efficient DLD Microfluidic Chip With Two\u2010Stage Inclined Elliptical Pillars for Particle Separation and Purification"],"prefix":"10.1002","author":[{"given":"Di","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Mechanical and Electronic Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Mechanical and Electronic Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Mechanical and Electronic Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Mechanical and Electronic Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Mechanical and Electronic Engineering Nanjing Forestry University  Nanjing 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